Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200066
Type: Artigo de periódico
Title: The Functional Role Of Ascending Nociceptive Control In Defensive Behavior.
Author: Tambeli, Claudia Herrera
Fischer, Luana
Monaliza, Simone Lamana
Menescal-de-Oliveira, Leda
Parada, Carlos Amílcar
Abstract: Ascending nociceptive control is a novel spino-striato-rostral ventral medulla pain modulation pathway that mediates heterosegmental pain-induced analgesia, i.e., noxious stimulus-induced antinociception. In this study, we used the dorsal immobility response in rats as a model of the defensive responses. We demonstrated that the activation of ascending nociceptive control by peripheral noxious stimulation and spinal AMPA and mGluR1 receptor blockade significantly potentiated the duration of the dorsal immobility response in rats via an opioid-dependent mechanism in the nucleus accumbens. These results demonstrated the functional role of ascending nociceptive control in the modulation of defensive responses and spinal glutamatergic receptors in the dorsal immobility response. The immobility response is an antipredator behavior that reflects the underlying state of fear, and ascending nociceptive control may modulate fear.
Subject: Animals
Benzoates
Excitatory Amino Acid Antagonists
Glycine
Immobility Response, Tonic
Male
Motor Activity
Neural Pathways
Nociception
Nucleus Accumbens
Pain
Quinoxalines
Rats
Rats, Wistar
Somatostatin
Rights: fechado
Identifier DOI: 10.1016/j.brainres.2012.05.010
Address: http://www.ncbi.nlm.nih.gov/pubmed/22709533
Date Issue: 2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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