Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200039
Type: Artigo de periódico
Title: Lack Of Association Between Mdm2 Snp309 And Tp53 Arg72pro Polymorphisms With Clinical Outcomes In Myelodysplastic Syndrome.
Author: Machado-Neto, J A
Traina, F
De Melo Campos, P
Andreoli-Risso, M F
Costa, F F
Olalla Saad, S T
Abstract: MDM2/p53 pathway plays an important role in the control of apoptotic and proliferation mechanisms, and alterations in this pathway have been described in myelodysplastic syndromes (MDS). We investigated the frequency of MDM2 SNP309, TP53 Arg72Pro polymorphisms in de novo MDS and the association of these polymorphisms with clinical characteristics. Our results showed that the frequencies of genotypes for MDM2 SNP309 and TP53 Arg72Pro did not differ between MDS and healthy controls and that these polymorphisms were not associated with clinical and laboratory parameters, disease progression and overall survival, suggesting that MDM2 and TP53 polymorphisms are not involved in risk for MDS, or in the clinical and laboratory characteristics of the disease.
Subject: Adolescent
Adult
Aged
Aged, 80 And Over
Case-control Studies
Dna, Neoplasm
Female
Humans
Male
Middle Aged
Myelodysplastic Syndromes
Neoplasm Staging
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Prognosis
Proto-oncogene Proteins C-mdm2
Survival Rate
Tumor Suppressor Protein P53
Young Adult
Rights: fechado
Identifier DOI: 10.4149/neo_2012_068
Address: http://www.ncbi.nlm.nih.gov/pubmed/22668018
Date Issue: 2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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