Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200034
Type: Artigo de periódico
Title: Metabolic Surgery For Non-obese Type 2 Diabetes: Incretins, Adipocytokines, And Insulin Secretion/resistance Changes In A 1-year Interventional Clinical Controlled Study.
Author: Geloneze, Bruno
Geloneze, Sylka Rodovalho
Chaim, Elinton
Hirsch, Fernanda Filgueira
Felici, Ana Claudia
Lambert, Giselle
Tambascia, Marcos Antonio
Pareja, José Carlos
Abstract: To compare duodenal-jejunal bypass (DJB) with standard medical care in nonobese patients with type 2 diabetes and evaluate surgically induced endocrine and metabolic changes. Eighteen patients submitted to a DJB procedure met the following criteria: overweight, diabetes diagnosis less than 15 years, current insulin treatment, residual β-cell function, and absence of autoimmunity. Patients who refused surgical treatment received standard medical care (control group). At baseline, 3, 6, and 12 months after surgery, insulin sensitivity and production of glucagon-like peptide-1 and glucose-insulinotropic polypeptide were assessed during a meal tolerance test. Fasting adipocytokines and dipeptidyl-peptidase-4 concentrations were measured. The mean age of the patients was 50 (5) years, time of diagnosis: 9 (2) years, time of insulin usage: 6 (5) months, fasting glucose: 9.9 (2.5) mmol/dL, and HbA1c (glycosylated hemoglobin) level: 8.9% (1.2%). Duodenal-jejunal bypass group showed greater reductions in fasting glucose (22% vs 6% in control group, P < 0.05) and daily insulin requirement (93% vs 15%, P < 0.01). Twelve patients from DJB group stopped using insulin and showed improvements in insulin sensitivity and β-cell function (P < 0.01), and reductions in glucose-insulinotropic polypeptide levels (P < 0.001), glucagon during the first 30 minutes after meal (P < 0.05), and leptin levels (P < 0.05). Dipeptidyl-peptidase-4 levels increased after surgery (P < 0.01), but glucagon-like peptide-1 levels did not change. Duodenal-jejunal bypass improved insulin sensitivity and β-cell function and reduced glucose-insulinotropic polypeptide, leptin, and glucagon production. Hence, DJB resulted in better glycemic control and reduction in insulin requirement but DJB did not result in remission of diabetes.
Subject: Blood Glucose
Diabetes Mellitus, Type 2
Digestive System Surgical Procedures
Dipeptidyl Peptidase 4
Duodenum
Gastric Inhibitory Polypeptide
Glucagon-like Peptide 1
Homeostasis
Humans
Incretins
Insulin Resistance
Jejunum
Middle Aged
Rights: fechado
Identifier DOI: 10.1097/SLA.0b013e3182592c62
Address: http://www.ncbi.nlm.nih.gov/pubmed/22664560
Date Issue: 2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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