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Type: Artigo de periódico
Title: Oxidized Low-density Lipoproteins And Their Antibodies: Relationships With The Reverse Cholesterol Transport And Carotid Atherosclerosis In Adults Without Cardiovascular Diseases.
Author: Ferreira, Paolla F C
Zago, Vanessa H S
D'Alexandri, Fabio L
Panzoldo, Natália B
Gidlund, Magnus A
Nakamura, Rui T
Schreiber, Roberto
Parra, Eliane S
Santiago, Fernanda D
Nakandakare, Edna R
Quintão, Eder C R
de Faria, Eliana C
Abstract: Metabolic predictors and the atherogenicity of oxidized LDL (oxLDL) and the specific antibodies against oxLDL (oxLDL Ab) are unclear and controversial. In 107 adults without atherosclerotic manifestations, we measured oxLDL and oxLDL Ab, and also the activities of CETP, PLTP, lipases and the carotid intima-media thickness (cIMT). Comparisons were performed for the studied parameters between the lowest and the highest tertile of oxLDL and oxLDL Ab, and the relationships between studied variables were evaluated. Subjects with higher oxLDL Ab present reduced hepatic lipase activity and borderline increased cIMT. In the highest oxLDL tertile, besides the higher levels of total cholesterol, LDL-C and apoB100, we found reduced CETP activity and higher cIMT. A significant correlation between oxLDL Ab and cIMT, independent of oxLDL, and a borderline correlation between oxLDL and cIMT independent of oxLDL Ab were found. In the multivariate analysis, apoAI was a significant predictor of oxLDL Ab, in contrast to regulation of oxLDL by apoB100, PLTP and inverse of CETP. In adults without atherosclerotic disease, the metabolic regulation and carotid atherosclerosis of oxLDL Ab and oxLDL groups, characterized a dual trait in oxLDL Ab, as a contributor to carotid atherosclerosis, much less so than oxidized LDL, and with a modest atheroprotective role.
Subject: Adult
Analysis Of Variance
Apolipoprotein B-100
Biological Transport
Carotid Arteries
Carotid Artery Diseases
Carotid Intima-media Thickness
Cholesterol Ester Transfer Proteins
Cholesterol, Ldl
Lipoproteins, Ldl
Middle Aged
Phospholipid Transfer Proteins
Risk Factors
Citation: Clinica Chimica Acta; International Journal Of Clinical Chemistry. v. 413, n. 19-20, p. 1472-8, 2012-Oct.
Rights: fechado
Identifier DOI: 10.1016/j.cca.2012.05.020
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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