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Type: Artigo de periódico
Title: Antioxidant Action Of Mangrove Polyphenols Against Gastric Damage Induced By Absolute Ethanol And Ischemia-reperfusion In The Rat.
Author: de-Faria, Felipe Meira
Almeida, Ana Cristina Alves
Luiz-Ferreira, Anderson
Takayama, Christiane
Dunder, Ricardo José
da Silva, Marcelo Aparecido
Salvador, Marcos José
Abdelnur, Patrícia Verardi
Eberlin, Marcos Nogueira
Vilegas, Wagner
Toma, Walber
Souza-Brito, Alba Regina Monteiro
Abstract: Rhizophora mangle, the red mangrove, has long been known as a traditional medicine. Its bark has been used as astringent, antiseptic, hemostatic, with antifungic and antiulcerogenic properties. In this paper, we aimed to evaluate the antioxidant properties of a buthanolic fraction of the R. mangle bark extract (RM) against experimental gastric ulcer in rats. Unib-Wh rats received pretreatment of R. mangle after the induction of gastric injury with absolute ethanol and ischemia-reperfusion. Gastric tissues from both methods were prepared to the enzymatic assays, the levels of sulfhydril compounds (GSH), lipid peroxides (LPO), and the activities of glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD) and myeloperoxidase (MPO) were measured. The RM protected the gastric mucosa in both methods used, ethanol-induced gastric ulcer and ischemia-reperfusion, probably, by modulating the activities of the enzymes SOD, GPx, and GR and increasing or maintaining the levels of GSH; in addition, LPO levels were reduced. The results suggest that the RM antioxidant activity leads to tissue protection; thus one of the antiulcer mechanisms present on the pharmacological effects of R. mangle is the antioxidant property.
Subject: Animals
Glutathione Peroxidase
Lipid Peroxidation
Lipid Peroxides
Plant Bark
Plant Extracts
Reperfusion Injury
Stomach Ulcer
Superoxide Dismutase
Rights: aberto
Identifier DOI: 10.1100/2012/327071
Date Issue: 2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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