Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200028
Type: Artigo de periódico
Title: Metastatic Mucinous Carcinomas In The Ovary: A Practical Approach To Diagnosis Related To Gross Aspects And To Immunohistochemical Evaluation.
Author: Pinto, Paola B Cardoso
Derchain, Sophie F M
Andrade, Liliana Aparecida Lucci De Angelo
Abstract: Ovarian mucinous carcinomas are uncommon, and the differential diagnosis is metastatic carcinoma mainly from the gastrointestinal tract. The aim was to verify the importance of immunohistochemical reactions and the algorithm described in literature on the basis of laterality and tumor size. Twenty-five cases identified as metastatic mucinous adenocarcinomas were reviewed, along with clinical records; a tissue microarray was created, and immunohistochemical reactions for CK7, CK20, Ca125, hormonal receptors, WT1, DPC4, β-catenin, and Cdx2 were determined. The median age was 51, and only 9 patients had a history of cancer. Sixteen patients (64%) had bilateral tumors, with sizes ranging from 5 to 36 cm (average, 20.5 cm); 9 (36%) had unilateral tumors varying from 5.5 to 38 cm (average, 21.8 cm). Algorithm agreement was 76%; most unilateral tumors were >13 cm. Common positive markers were Dpc4 (88%), Cdx2 (68%), CK20 (60%), and CK7 (44%). The useful markers were CK7, CK20, and Cdx2, although there were cases with overlapping results. The most common primary tumor was of colorectal origin (14 cases). The mean survival age was 32.6 mo. Although the proposed algorithm and immunohistochemical reactions are useful tools for diagnosis, some mucinous tumors cannot be definitively classified as primary or metastatic without further clinical evaluation, emphasizing the limits of this challenging diagnosis.
Subject: Adenocarcinoma, Mucinous
Adult
Aged
Algorithms
Diagnosis, Differential
Female
Humans
Immunohistochemistry
Kaplan-meier Estimate
Middle Aged
Ovarian Neoplasms
Retrospective Studies
Tissue Array Analysis
Tumor Markers, Biological
Citation: International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists. v. 31, n. 4, p. 313-8, 2012-Jul.
Rights: fechado
Identifier DOI: 10.1097/PGP.0b013e31823f844d
Address: http://www.ncbi.nlm.nih.gov/pubmed/22653343
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_22653343.pdf211.5 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.