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Type: Artigo de periódico
Title: [prostate Cancer: Promising Biomarkers Related To Aggressive Disease].
Author: Ribeiro da Silva, M N
Tobias-Machado, M
Lima-Pompeo, A C
Reis, L O
da Silva Pinhal, M A
Abstract: Although a rapidly growing number of candidate biological markers of prognosis and/or response to specific treatments in prostate cancer, none have to date showed ability to completely prognosticate prostate cancer on evidence based urology. To review the pertinent literature on the issue. A comprehensive review of the current literature was done focusing on promising biomarkers related to aggressive prostate cancer. Combined with the heterogeneous nature of the disease, mixed case series are the most common study design, impeding robust results and the development of an effective therapeutic strategy. Improvement in prostate cancer patient survival requires not only the identification of new therapeutic target based on detailed understanding of the biological mechanisms involved in metastatic dissemination and tumor growth but strong clinical studies as well. Better study design involving potential markers and including well-classified and staged patients with robust methodology and adequate outcomes (mainly survival) are necessary to the field evolution.
Subject: Biological Markers
Prostatic Neoplasms
Severity Of Illness Index
Rights: fechado
Identifier DOI: 10.1016/j.acuro.2011.11.017
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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