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Type: Artigo de periódico
Title: Expression Of Cyclooxygenase-2 (cox-2) And P53 In Neighboring Invasive And In Situ Components Of Breast Tumors.
Author: Serra, Katia Piton
Sarian, Luis Otavio
Rodrigues-Peres, Raquel Mary
Vassallo, José
Soares, Fernando Augusto
Pinto, Glauce Aparecida
da Cunha, Isabela Werneck
Shinzato, Julia Yoriko
Derchain, Sophie F M
Abstract: The aim of the study was to assess the relationship between the expression of COX-2 and p53, hormone receptors and HER-2 in the in situ (DCIS) and invasive components of ductal carcinomas (IDC) of the same breast. The expression of COX-2, p53, and hormone receptors was assessed in 87 cases of IDC with contiguous areas of DCIS. Results showed that there was no difference in COX-2 expression comparing the in situ and invasive components of the tumors. In the in situ component, there was a statistically borderline increase in p53 expression in tumors that also expressed COX-2. ER-positive specimens were more common in the group of tumors that expressed COX-2 in the invasive component. From this study we conclude that the expression of COX-2 was similar in the in situ and invasive components of the breast carcinomas. COX-2 positivity was marginally related with the expression of p53 in the in situ components, and with the ER expression in the invasive components.
Subject: Aged
Breast Neoplasms
Carcinoma, Ductal
Cyclooxygenase 2
Gene Expression
In Situ Hybridization, Fluorescence
Middle Aged
Neoplasm Invasiveness
Receptor, Erbb-2
Receptors, Estrogen
Tumor Markers, Biological
Tumor Microenvironment
Tumor Suppressor Protein P53
Citation: Acta Histochemica. v. 114, n. 3, p. 226-31, 2012-May.
Rights: fechado
Identifier DOI: 10.1016/j.acthis.2011.05.001
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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