Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199900
Type: Artigo de periódico
Title: Iron Chelation Therapy In The Management Of Transfusion-related Cardiac Iron Overload.
Author: Fernandes, Juliano Lara
Abstract: Iron overload is one of the major causes of morbidity and death in patients undergoing chronic transfusion therapy. Furthermore, excessive iron accumulation in the heart may result in impaired left ventricular dysfunction. With accurate monitoring techniques and treatment regimens, progression of heart complications can be followed, and their natural history changed. Iron chelation therapy is the mainstay of prevention and reversal of myocardial iron overload. Despite recent appraisals of general chelating strategies, the management of iron chelation in chronically transfused patients with a focus on the heart has not been extensively assessed. New studies published in the past couple of years have provided important new data in this topic and therefore this review summarizes the major studies that examined the removal of iron from the heart with the iron chelators: deferoxamine, deferiprone, and deferasirox. Since chronically transfused patients and their cardiac clinical presentations vary widely, this review tries to identify--with each drug--the precise scenarios evaluated, linking patients' baseline characteristics, clinical setting, and drug intake and dosing. Ultimately, by stratifying patients according to their cardiac iron overload status and ventricular function, this review identifies possible approaches for the initial treatment and follow-up of transfusion-related cardiac iron overload.
Subject: Benzoates
Blood Transfusion
Cardiomyopathy, Dilated
Chelation Therapy
Cross-sectional Studies
Deferoxamine
Double-blind Method
Drug Therapy, Combination
Forecasting
Humans
Iron Chelating Agents
Iron Overload
Magnetic Resonance Imaging
Practice Guidelines As Topic
Prospective Studies
Pyridones
Randomized Controlled Trials As Topic
Retrospective Studies
Treatment Outcome
Triazoles
Ventricular Dysfunction, Left
Rights: fechado
Identifier DOI: 10.1111/j.1537-2995.2012.03580.x
Address: http://www.ncbi.nlm.nih.gov/pubmed/22404719
Date Issue: 2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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