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dc.typeArtigo de periódicopt_BR
dc.titleParaganglioma Of Seminal Vesicle And Chromophobe Renal Cell Carcinoma: A Case Report And Literature Review.pt_BR
dc.contributor.authorAlvarenga, César Augustopt_BR
dc.contributor.authorLopes, José Manuelpt_BR
dc.contributor.authorVinagre, Joãopt_BR
dc.contributor.authorParavidino, Paula Itagybapt_BR
dc.contributor.authorAlvarenga, Marcelopt_BR
dc.contributor.authorPrando, Adilsonpt_BR
dc.contributor.authorCastilho, Lísias Nogueirapt_BR
dc.contributor.authorSoares, Paulapt_BR
dc.contributor.authorBillis, Athanasept_BR
unicamp.authorCésar Augusto Alvarenga, Department of Pathology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil. cesalvarenga@gmail.compt_BRé Manuel Lopes,ptão Vinagre,pt Itagyba Paravidino,pt Alvarenga,pt Prando,ptísias Nogueira Castilho,pt Soares,pt Billis,pt
dc.subjectCarcinoma, Renal Cellpt_BR
dc.subjectDiagnosis, Differentialpt_BR
dc.subjectGenital Neoplasms, Malept_BR
dc.subjectKidney Neoplasmspt_BR
dc.subjectMiddle Agedpt_BR
dc.subjectNeoplasms, Multiple Primarypt_BR
dc.subjectSeminal Vesiclespt_BR
dc.subjectSuccinate Dehydrogenasept_BR
dc.subjectVon Hippel-lindau Tumor Suppressor Proteinpt_BR
dc.description.abstractExtra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.en
dc.relation.ispartofSão Paulo Medical Journal = Revista Paulista De Medicinapt_BR
dc.relation.ispartofabbreviationSao Paulo Med Jpt_BR
dc.identifier.citationSão Paulo Medical Journal = Revista Paulista De Medicina. v. 130, n. 1, p. 57-60, 2012.pt_BR
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