Please use this identifier to cite or link to this item:
http://repositorio.unicamp.br/jspui/handle/REPOSIP/199877
Type: | Artigo de periódico |
Title: | Paraganglioma Of Seminal Vesicle And Chromophobe Renal Cell Carcinoma: A Case Report And Literature Review. |
Author: | Alvarenga, César Augusto Lopes, José Manuel Vinagre, João Paravidino, Paula Itagyba Alvarenga, Marcelo Prando, Adilson Castilho, Lísias Nogueira Soares, Paula Billis, Athanase |
Abstract: | Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension. |
Subject: | Carcinoma, Renal Cell Diagnosis, Differential Genital Neoplasms, Male Humans Hypertension Kidney Neoplasms Male Middle Aged Neoplasms, Multiple Primary Paraganglioma Seminal Vesicles Succinate Dehydrogenase Von Hippel-lindau Tumor Suppressor Protein |
Citation: | São Paulo Medical Journal = Revista Paulista De Medicina. v. 130, n. 1, p. 57-60, 2012. |
Rights: | aberto |
Identifier DOI: | |
Address: | http://www.ncbi.nlm.nih.gov/pubmed/22344361 |
Date Issue: | 2012 |
Appears in Collections: | Unicamp - Artigos e Outros Documentos |
Files in This Item:
File | Size | Format | |
---|---|---|---|
pmed_22344361.pdf | 860.51 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.