Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199877
Type: Artigo de periódico
Title: Paraganglioma Of Seminal Vesicle And Chromophobe Renal Cell Carcinoma: A Case Report And Literature Review.
Author: Alvarenga, César Augusto
Lopes, José Manuel
Vinagre, João
Paravidino, Paula Itagyba
Alvarenga, Marcelo
Prando, Adilson
Castilho, Lísias Nogueira
Soares, Paula
Billis, Athanase
Abstract: Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.
Subject: Carcinoma, Renal Cell
Diagnosis, Differential
Genital Neoplasms, Male
Humans
Hypertension
Kidney Neoplasms
Male
Middle Aged
Neoplasms, Multiple Primary
Paraganglioma
Seminal Vesicles
Succinate Dehydrogenase
Von Hippel-lindau Tumor Suppressor Protein
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/22344361
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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