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Type: Artigo de periódico
Title: Levels And Patterns Of Expression Of Hypoxia-inducible Factor-1α, Vascular Endothelial Growth Factor, Glucose Transporter-1 And Cd105 In Adenoid Cystic Carcinomas With High-grade Transformation.
Author: Costa, Ana F
Tasso, Marcelo G
Mariano, Fernanda V
Soares, Andresa B
Chone, Carlos T
Crespo, Agricio N
Fresno, Manuel F
Llorente, Jose L
Suárez, Carlos
de Araújo, Vera C
Hermsen, Mario
Altemani, Albina
Abstract: To compare the expression of proteins regulated by hypoxia between adenoid cystic carcinoma (ACC) with and without high-grade transformation (HGT).   In eight ACC-HGT and 18 ACC without HGT, expression of hypoxia-inducible factor-1 (HIF-1α), vascular endothelial growth factor (VEGF), glucose transporter-1 (GLUT-1) and microvascular density (MVD) by CD105 (a hypoxia-inducible protein expressed in angiogenic endothelial cells) was determined. Expression levels of HIF-1α and VEGF as well as CD105-MVD did not differ significantly between: (i) transformed and conventional areas (TA and CA, respectively) of ACC-HGT, (ii) CA and ordinary ACC. HIF-1α was detected in 100% of cases and presented a diffuse expression pattern. No significant association was found between levels of HIF-1α expression and tumour size, metastasis and recurrence. GLUT-1 showed a prostromal expression pattern and was observed exclusively in TA (three of six cases) and in only three of 14 ACC. Both the absence of significant alterations in levels of expression of HIF-1α, VEGF and CD105 and the patterns of expression of HIF-1α and GLUT-1 suggest that hypoxia may not play a key role in the process of high-grade transformation of ACC. Although HIF-1α expression is a common finding in ACC, it cannot be used as a marker of tumour aggressiveness.
Subject: Adult
Antigens, Cd
Carcinoma, Adenoid Cystic
Cell Transformation, Neoplastic
Combined Modality Therapy
Glucose Transporter Type 1
Head And Neck Neoplasms
Hypoxia-inducible Factor 1, Alpha Subunit
Middle Aged
Receptors, Cell Surface
Survival Rate
Tumor Markers, Biological
Vascular Endothelial Growth Factor A
Young Adult
Rights: fechado
Identifier DOI: 10.1111/j.1365-2559.2011.04128.x
Date Issue: 2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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