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Type: Artigo de periódico
Title: Immunohistochemical Expression Of P16, P21, P27 And Cyclin D1 In Oral Nevi And Melanoma.
Author: de Andrade, Bruno Augusto Benevenuto
León, Jorge Esquiche
Carlos, Román
Delgado-Azañero, Wilson
Mosqueda-Taylor, Adalberto
de Almeida, Oslei Paes
Abstract: The acquisition of abnormalities at G1/S is considered a crucial step in the genesis and progression of melanoma. The expression of cell cycle regulators has also been used in various neoplasms as an adjunct to diagnosis. The aim of this study was to compare the expression of p16, p21, p27 and cyclin D1 in oral nevi and melanomas. Expression of these cell cycle regulatory proteins was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas. p16 and p27 were highly expressed in intramucosal nevi, whereas p21 and cyclin D1 expression was higher in oral melanomas. The results indicate that p21 and cyclin D1 may be involved in the development of oral melanomas, and eventually they may be useful in the differential diagnoses of oral benign and malignant melanocytic lesions.
Subject: Adolescent
Cyclin D1
Cyclin-dependent Kinase Inhibitor P21
Cyclin-dependent Kinase Inhibitor P27
Middle Aged
Mouth Neoplasms
Neoplasm Proteins
Tumor Markers, Biological
Young Adult
Citation: Head And Neck Pathology. v. 6, n. 3, p. 297-304, 2012-Sep.
Rights: fechado
Identifier DOI: 10.1007/s12105-012-0334-y
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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