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Type: Artigo de periódico
Title: Chemical, Spectroscopic Characterization, Dft Studies And Antibacterial Activities In Vitro Of A New Gold(i) Complex With Rimantadine.
Author: Sucena, Suelen F
Paiva, Raphael E F
Abbehausen, Camilla
Mattos, Ives B
Lancellotti, Marcelo
Formiga, André L B
Corbi, Pedro P
Abstract: A novel gold(I) complex with rimantadine (RTD) was obtained and structurally characterized by a set of chemical and spectroscopic analysis. 1H, 13C and 15N nuclear magnetic resonance (NMR) and infrared (IR) spectroscopic measurements suggest coordination of the ligand to Au(I) through the N atom of the ethanamine group. Theoretical (DFT) calculations confirmed the IR assignments and permit proposing an optimized geometry for the complex. The gold(I)-rimantadine complex (Au-RTD) is soluble in methanol, ethanol, dimethylsulfoxide, acetone and acetonitrile. The preliminary kinetic studies based on UV-vis spectroscopic measurements indicate the stability of the compound in solution. Antibacterial activities of the complex were evaluated by an antibiogram assay. The Au-RTD complex showed an effective in vitro antibacterial activity against the Pseudomonas aeruginosa, Escherichia coli (Gram-negative), and Staphylococcus aureus (Gram-positive) bacterial strains.
Subject: Anti-bacterial Agents
Bacterial Infections
Escherichia Coli
Magnetic Resonance Spectroscopy
Models, Molecular
Organogold Compounds
Pseudomonas Aeruginosa
Spectrophotometry, Infrared
Staphylococcus Aureus
Rights: fechado
Identifier DOI: 10.1016/j.saa.2011.12.043
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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