Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199844
Type: Artigo de periódico
Title: Comparison Of Metabolic Effects Of Surgical-induced Massive Weight Loss In Patients With Long-term Remission Versus Non-remission Of Type 2 Diabetes.
Author: Hirsch, Fernanda Filgueira
Pareja, Jose Carlos
Geloneze, Sylka Rodovalho
Chaim, Elinton
Cazzo, Everton
Geloneze, Bruno
Abstract: The aim of this study was to evaluate the pathophysiological mechanisms underlying the non-remission of type 2 diabetes in Roux-en-Y gastric bypass (RYGB) patients. A group of patients not in remission (NR) was formed (n = 13). A remission group (R) was composed of patients who had undergone normalization of fasting glycemia and A1c, without anti-diabetic drugs and matched for selected baseline characteristics (i.e., duration of disease, previous BMI, final BMI, fat distribution, and age; n = 15). A control group of lean subjects (n = 41) was formed. The NR group had higher uric acid (5.1 vs. 3.9 mg/dL), number of leukocytes (6,866.9 vs. 5,423.6), hs-CRP (0.27 vs. 0.12 mg/dL), MCP-1 (118.4 vs. 64.4 ng/mL), HOMA-IR, and AUC(glucose) but lower adiponectin (9.4 vs. 15.4 ng/mL), leptin (12.7 vs. 20.7 ng/mL), and AUC(GLP-1) in comparison to R group; the NR group also had lower leptin and higher adiponectin, HOMA-IR, AUC(glucose), AUC(C-peptide), AUC(glucagon), and AUC(GLP-1) than controls. The R group had lower MCP-1 and higher adiponectin compared to controls. Insulin sensitivity was significantly lower in the NR group than in the R and control groups. The insulin secretion index values were lower in the NR group than in the R and control groups. This study found greater insulin resistance, lower insulin secretion, persistent adiposopathy and chronic subclinical inflammation, and less robust incretin response in the NR group despite a similar level of weight loss. Persistently altered pathophysiological mechanisms can be related to the lack of remission of type 2 diabetes after RYGB.
Subject: Adiponectin
Adolescent
Adult
Area Under Curve
Blood Glucose
Body Mass Index
Brazil
C-reactive Protein
Diabetes Mellitus, Type 2
Female
Gastric Bypass
Glucagon-like Peptide 1
Humans
Incretins
Leukocytes
Male
Middle Aged
Obesity, Morbid
Remission Induction
Retrospective Studies
Uric Acid
Weight Loss
Young Adult
Rights: fechado
Identifier DOI: 10.1007/s11695-012-0589-0
Address: http://www.ncbi.nlm.nih.gov/pubmed/22246393
Date Issue: 2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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