Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199823
Type: Artigo de periódico
Title: Histometric Analysis Of Bone Repair In Bone-implant Interface Using A Polylactic/polyglycolic Acid Copolymer Associated With Implants In Rabbit Tibia.
Author: Freire, Alexandre Rodrigues
Rossi, Ana Cláudia
Queiroz, Thallita Pereira
Gulinelli, Jéssica Lemos
Souza, Francisley Ávila
Margonar, Rogério
Garcia-Júnior, Idelmo Rangel
Hochuli-Vieira, Eduardo
Okamoto, Roberta
Abstract: The purpose of this study was to evaluate the association of the combination of polylactic/polyglycolic acid around implants installed with and without primary stability through the histometric analysis of bone-implant interface. We used male rabbits, each of which received 2 titanium implants in each tibial metaphysis. The animals were divided into 4 groups: control with primary stability (CPS), control without primary stability (C), polymer with primary stability (PPS), and polymer without primary stability (P). Euthanasia was performed at postoperative days 40 and 90. The pieces were embedded in resin, sectioned, scraped, and stained with alizarin red and Stevenel blue. Histometric analysis evaluated the linear extension of contact between the bone and implant surface on the implant collar (CIC) and contact between the bone and implant surface on the first thread (CFT). Also evaluated was the area of newly formed bone (ANB) in the first thread. The results showed that there was new bone formation in all groups and during all periods. At 40 days, the ANB was higher in the PPS group than in the P group (P < .001); the CFT was statistically higher in the CPS group than the PPS group (P < .001) and was higher in the CPS group than the C group (P < .001). At 40 and 90 days, the CIC was higher in the P group than in the C group (P < .001). In conclusion, the copolymer had biocompatibility, enhanced bone healing, and presented osteoconductive properties, thus raising the contact between bone and implant, even without primary stability.
Subject: Animals
Bone Cements
Bone Regeneration
Bone Substitutes
Dental Implants
Dental Prosthesis Retention
Lactic Acid
Longitudinal Studies
Male
Osseointegration
Polyglycolic Acid
Rabbits
Tibia
Rights: fechado
Identifier DOI: 10.1563/AAID-JOI-D-10-00102
Address: http://www.ncbi.nlm.nih.gov/pubmed/21142786
Date Issue: 2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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