Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199820
Type: Artigo
Title: Liposomal delivery system for topical anaesthesia of the palatal mucosa.
Author: Franz-Montan, M.
de Paula, E.
Groppo, F. C.
Silva, A. L. R.
Ranali, J.
Volpato, M. C.
Abstract: An effective topical agent to reduce pain during local anaesthesia of the palate is not yet available. The aim of the present study was to evaluate the efficiency of liposome-encapsulated ropivacaine in different concentrations for topical anaesthesia of the palatal mucosa. In this single-blinded, placebo-controlled, crossover study 40 (20 male) healthy volunteers were randomised to be given: liposome-encapsulated 2% ropivacaine, liposome-encapsulated 1% ropivacaine, a eutectic mixture of 2.5% lidocaine and 2.5% prilocaine (EMLA), and liposomal placebo gel, topically on to the palatal mucosa of the right canine region for 5 min each, at four different sessions. Pain associated with insertion of a 30G needle, and with injection of a local anaesthetic, was rated on a visual analogue scale (VAS). The effect of liposomal ropivacaine 1% and 2% did not differ from that of placebo (p=0.3 and p=0.1, respectively) in reducing pain during insertion of the needle. Lower VAS were obtained with EMLA. In this group VAS were lower in women than men (p=0.007). There was no difference in VAS among groups (p=0.3) as far as injection of the local anaesthetic was concerned. In conclusion, liposomal-encapsulated ropivacaine formulations did not reduce the pain of insertion of a needle into the palatal mucosa. None of the anaesthetic formulations tested, including the positive control (EMLA), were effective in reducing the pain of an injection of local anaesthetic compared with placebo.
Subject: Anestésicos locais
Ropivacaína
Mucosa bucal
Country: Reino Unido
Editor: Elsevier
Rights: fechado
Identifier DOI: 10.1016/j.bjoms.2010.10.018
Address: https://www.sciencedirect.com/science/article/pii/S0266435610003517
Date Issue: 2012
Appears in Collections:IB - Artigos e Outros Documentos
FOP - Artigos e Outros Documentos

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