Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199810
Type: Artigo de periódico
Title: The Contribution Of Hypertension To Diabetic Nephropathy And Retinopathy: The Role Of Inflammation And Oxidative Stress.
Author: Lopes de Faria, José Butori
Silva, Kamila Cristina
Lopes de Faria, Jacqueline Mendonça
Abstract: Diabetes and hypertension frequently coexist and constitute the most notorious combination for the pathogenesis of diabetic nephropathy and retinopathy. Large clinical trials have clearly demonstrated that tight control of glycemia and/or blood pressure significantly reduces the incidence and progression of diabetic retinopathy (DR) and nephropathy. However, the mechanism by which hypertension interacts with diabetes to induce and/or exacerbate nephropathy and retinopathy is very unclear. Substantial evidence implicates the involvement of chronic inflammation and oxidative stress in the pathogenesis of DR and nephropathy. In addition, hypertension causes oxidative stress and inflammation in the kidney and retina. In the present review, we summarized data obtained from our research along with those from other groups to better understand the role of hypertension in the pathogenesis of diabetic nephropathy and retinopathy. It is suggested that oxidative stress and inflammation may be common denominators of kidney and retinal damage in the concomitant presence of diabetes and hypertension.
Subject: Comorbidity
Diabetic Nephropathies
Diabetic Retinopathy
Humans
Hypertension
Inflammation
Kidney
Oxidative Stress
Retina
Citation: Hypertension Research : Official Journal Of The Japanese Society Of Hypertension. v. 34, n. 4, p. 413-22, 2011-Apr.
Rights: aberto
Identifier DOI: 10.1038/hr.2010.263
Address: http://www.ncbi.nlm.nih.gov/pubmed/21228783
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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