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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEicosapentaenoic Acid Decreases Tnf-α And Protects Dystrophic Muscles Of Mdx Mice From Degeneration.pt_BR
dc.contributor.authorMachado, Rafael Venturapt_BR
dc.contributor.authorMauricio, Adriana Fogagnolopt_BR
dc.contributor.authorTaniguti, Ana Paula Tiemipt_BR
dc.contributor.authorFerretti, Renatopt_BR
dc.contributor.authorNeto, Humberto Santopt_BR
dc.contributor.authorMarques, Maria Juliapt_BR
unicamp.authorRafael Ventura Machado, Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, São Paulo 13083-970, Brazil.pt_BR
unicamp.author.externalAdriana Fogagnolo Mauricio,pt
unicamp.author.externalAna Paula Tiemi Taniguti,pt
unicamp.author.externalRenato Ferretti,pt
unicamp.author.externalHumberto Santo Neto,pt
unicamp.author.externalMaria Julia Marques,pt
dc.subjectAnimalspt_BR
dc.subjectBlotting, Westernpt_BR
dc.subjectCreatine Kinasept_BR
dc.subjectEicosapentaenoic Acidpt_BR
dc.subjectFemalept_BR
dc.subjectMalept_BR
dc.subjectMicept_BR
dc.subjectMice, Inbred Mdxpt_BR
dc.subjectMuscle, Skeletalpt_BR
dc.subjectMuscular Dystrophy, Animalpt_BR
dc.subjectNecrosispt_BR
dc.subjectTumor Necrosis Factor-alphapt_BR
dc.description.abstractIn dystrophin-deficient fibers of mdx mice and in Duchenne muscular dystrophy, inflammation and increased production of tumor necrosis factor alpha (TNF-α) contribute to myonecrosis. We examined the effects of eicosapentaenoic acid (EPA) on dystrophic muscle degeneration. Mdx mice (14 days old) received EPA for 16 days. The sternomastoid, diaphragm and biceps brachii muscles were removed. Control mdx mice received vehicle. EPA decreased creatine kinase and myonecrosis and reduced the levels of TNF-α. These results suggest that EPA plays a protective role in dystrophic muscle degeneration, possibly by reducing TNF-α, and support further investigations of EPA as a potential therapy for dystrophinopathies.en
dc.relation.ispartofJournal Of Neuroimmunologypt_BR
dc.relation.ispartofabbreviationJ. Neuroimmunol.pt_BR
dc.date.issued2011-Marpt_BR
dc.identifier.citationJournal Of Neuroimmunology. v. 232, n. 1-2, p. 145-50, 2011-Mar.pt_BR
dc.language.isoengpt_BR
dc.description.volume232pt_BR
dc.description.firstpage145-50pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright © 2010 Elsevier B.V. All rights reserved.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1872-8421pt_BR
dc.identifier.doi10.1016/j.jneuroim.2010.10.032pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21131061pt_BR
dc.date.available2015-11-27T13:22:13Z-
dc.date.accessioned2015-11-27T13:22:13Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:22:13Z (GMT). No. of bitstreams: 1 pmed_21131061.pdf: 583582 bytes, checksum: 13ad24533b1f63273f5915223263601b (MD5) Previous issue date: 2011en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199780-
dc.identifier.idPubmed21131061pt_BR
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