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Type: Artigo de periódico
Title: Eicosapentaenoic Acid Decreases Tnf-α And Protects Dystrophic Muscles Of Mdx Mice From Degeneration.
Author: Machado, Rafael Ventura
Mauricio, Adriana Fogagnolo
Taniguti, Ana Paula Tiemi
Ferretti, Renato
Neto, Humberto Santo
Marques, Maria Julia
Abstract: In dystrophin-deficient fibers of mdx mice and in Duchenne muscular dystrophy, inflammation and increased production of tumor necrosis factor alpha (TNF-α) contribute to myonecrosis. We examined the effects of eicosapentaenoic acid (EPA) on dystrophic muscle degeneration. Mdx mice (14 days old) received EPA for 16 days. The sternomastoid, diaphragm and biceps brachii muscles were removed. Control mdx mice received vehicle. EPA decreased creatine kinase and myonecrosis and reduced the levels of TNF-α. These results suggest that EPA plays a protective role in dystrophic muscle degeneration, possibly by reducing TNF-α, and support further investigations of EPA as a potential therapy for dystrophinopathies.
Subject: Animals
Blotting, Western
Creatine Kinase
Eicosapentaenoic Acid
Mice, Inbred Mdx
Muscle, Skeletal
Muscular Dystrophy, Animal
Tumor Necrosis Factor-alpha
Citation: Journal Of Neuroimmunology. v. 232, n. 1-2, p. 145-50, 2011-Mar.
Rights: fechado
Identifier DOI: 10.1016/j.jneuroim.2010.10.032
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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