Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199749
Type: Artigo de periódico
Title: Oral Lesions Associated With Hydroxyurea Treatment.
Author: Mendonça, Regina
Gueiros, Luiz Alcino
Capellaro, Kátia
Pinheiro, Vitória Régia Pereira
Lopes, Márcio Ajudarte
Abstract: Hydroxyurea (HU) is an antimetabolic agent commonly used in myeloproliferative disorders and hematological diseases as well as in severe psoriasis. Despite of usually be well tolerated, sometimes it can induce immunosuppression and mucocutaneous adverse effects associated with discomfort or pain. Nevertheless, oral mucosal adverse reactions are extremely uncommon and present as ulcers, tongue depapilation and dyschromia. Complete remission of adverse effects is usually observed after withdrawal of the medication. The aim of this paper is to report two patients with oral lesions related to HU treatment. T0 he patients were adequately managed by changing hydroxyurea with imatinib mesilate. Oral lesions are rare complications of long-term hydroxyurea treatment and may be an indication of stopping therapy and substitution with imatinib mesilate.
Subject: Adolescent
Adult
Antineoplastic Agents
Benzamides
Gingival Diseases
Humans
Hydroxyurea
Leukemia, Myelogenous, Chronic, Bcr-abl Positive
Lip Diseases
Male
Mouth Diseases
Mouth Floor
Mouth Mucosa
Oral Ulcer
Piperazines
Pyrimidines
Tongue Diseases
Rights: aberto
Identifier DOI: 10.4103/0970-9290.94690
Address: http://www.ncbi.nlm.nih.gov/pubmed/22484890
Date Issue: -1-Uns- -1
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
File SizeFormat 
pmed_22484890.pdf1.03 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.