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Type: Artigo de periódico
Title: Direct Monitoring Of Drug Degradation By Easy Ambient Sonic-spray Ionization Mass Spectrometry: The Case Of Enalapril.
Author: Amaral, Phellipe H
Fernandes, Raquel
Eberlin, Marcos N
Höehr, Nelci F
Abstract: Using enalapril maleate as a test case, the ability of ambient mass spectrometry, namely, via easy ambient sonic-spray ionization mass spectrometry (EASI-MS), to perform direct monitoring of drug degradation has been tested. Two manufacturing processes were investigated (direct compression and wet granulation), and the formation of degradation products was measured via both EASI-MS and high-performance liquid chromatography with ultraviolet detection for a total period of 18 months. Both techniques provide comparable results, which indicate that direct analysis by ambient mass spectrometric techniques presents a viable alternative for drug degradation monitoring with superior simplicity, throughput, and reliability (no sample manipulation), and comparable quantitative results. In terms of qualitative monitoring, the full mass spectra with intact species provided by EASI-MS allow for comprehensive monitoring of known and unknown (or unexpected) degradation products.
Subject: Drug Stability
Spectrometry, Mass, Electrospray Ionization
Rights: fechado
Identifier DOI: 10.1002/jms.2014
Date Issue: 2011
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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