Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: [levothyroxine And The Problem Of Interchangeability Of Drugs With Narrow Therapeutic Index].
Author: Ward, Laura Sterian
Abstract: The exchange of a prescribed drug by other similar, by generic products and even by custom products has become common practice in our country, often ignoring basic tenets of bioequivalence, interchangeability, stability and characteristics of the pharmaceutical compounds. In the case of drugs of narrow therapeutic index, such as levothyroxine, these problems are intensified, putting the effectiveness of treatment and patient health at serious risk. We review the pertinent legislation, emphasizing the characteristics of levothyroxine and adverse effects that limit the interchangeability of the compound.
Subject: Adverse Drug Reaction Reporting Systems
Drug Approval
Drug Substitution
Drugs, Generic
Therapeutic Equivalency
Thyroid Hormones
Citation: Arquivos Brasileiros De Endocrinologia E Metabologia. v. 55, n. 7, p. 429-34, 2011-Oct.
Rights: aberto
Identifier DOI: 
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_22147090.pdf1.49 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.