Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/1996
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePrimary nasal mucosal melanoma in Brazil: clinicopathologic and immunohistochemical study of 12 patientspt_BR
dc.contributor.authorBenevenuto de Andrade, Bruno Augustopt_BR
dc.contributor.authorPina, Alicia Rumayorpt_BR
dc.contributor.authorLeon, Jorge Esquichept_BR
dc.contributor.authorde Almeida, Oslei Paespt_BR
dc.contributor.authorAltemani, Albinapt_BR
unicamp.authorBenevenuto de Andrade, Bruno Augustopt_BR
unicamp.authorPina, Alicia Rumayorpt_BR
unicamp.authorLeon, Jorge Esquichept_BR
unicamp.authorde Almeida, Oslei Paespt_BR
unicamp.authorAltemani, Albinapt_BR
dc.subjectNasal melanomapt_BR
dc.subjectHistopathologypt_BR
dc.subjectImmunohistochemistrypt_BR
dc.subjectDiagnosispt_BR
dc.subject.wosACID SYNTHASE EXPRESSIONpt_BR
dc.subject.wosMALIGNANT-MELANOMApt_BR
dc.subject.wosSINONASAL MELANOMApt_BR
dc.subject.wosHEADpt_BR
dc.subject.wosNECKpt_BR
dc.subject.wosEXPERIENCEpt_BR
dc.subject.wosDIAGNOSISpt_BR
dc.subject.wosMARKERSpt_BR
dc.subject.wosCAVITYpt_BR
dc.subject.wosNEVIpt_BR
dc.description.abstractPrimary nasal melanoma is a rare tumor of unknown etiopathogenesis that occurs in adult and elderly patients usually diagnosed at advanced stages. The aim of this study was to analyze the clinicopathologic and immunohistochemical characteristics of 12 cases of primary nasal melanomas in Brazil. Twelve cases of primary nasal melanoma were analyzed histologically and by immunohistochemistry using the antibodies S-100 protein, HMB-45, Melan-A, CD63 (NKI/C3), CD68/KP1, fatty acid synthase (FASN), and Ki-67. The mean age of the patients was 60 years, and 7 of 12 patients were men. Microscopically, 10 cases presented level ill of invasion; 4 were amelanotic; and in 7, cells were epithelioid. S-100 protein and FASN were positive in all cases, whereas 9, 8, 7, and 6 cases were positive for HMB-45, Melan-A, CD63 (NKI/C3), and CD68/KP1, respectively. Ki-67 labeling index ranged from 11.45% to 28.5% of positive cells. S-100 protein is more frequently expressed in nasal melanomas than in HMB-45, Melan-A, CD63 (NKI/C3), and CD68/KP1. FASN seems to be involved in the pathogenesis of nasal melanomas, and also, it can be helpful to confirm the diagnosis. (C) 2012 Elsevier Inc. All rights reserved.pt
dc.relation.ispartofAnnals of Diagnostic Pathologypt_BR
dc.publisher.cityNew Yorkpt_BR
dc.publisherElsevierpt_BR
dc.date.issued2012pt_BR
dc.identifier.citationAnnals of Diagnostic Pathology. Elsevier, v.16, n.5, p.344-349, 2012pt_BR
dc.language.isoengpt_BR
dc.description.volume16pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage344pt_BR
dc.description.lastpage349pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1092-9134pt_BR
dc.identifier.wosidWOS:000308845600005pt_BR
dc.identifier.doi10.1016/j.anndiagpath.2012.02.001pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipNational Council for Scientific and Technological Developmentpt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2013-09-19T18:06:14Z
dc.date.available2016-06-30T20:33:50Z-
dc.date.accessioned2013-09-19T18:06:14Z
dc.date.accessioned2016-06-30T20:33:50Z-
dc.description.provenanceMade available in DSpace on 2013-09-19T18:06:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.description.provenanceMade available in DSpace on 2016-06-30T20:33:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/1996
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/1996-
dc.contributor.departmentDiagnóstico Oral
dc.contributor.unidadeFOPpt
Appears in Collections:FOP - Artigos e Outros Documentos

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