Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199697
Type: Artigo de periódico
Title: Age-related Changes In Dystrophin-glycoprotein Complex And In Utrophin Are Not Correlated With Intrinsic Laryngeal Muscles Protection In Mdx Mice.
Author: Ferretti, Renato
Pertille, Adriana
Santo Neto, Humberto
Marques, Maria Julia
Abstract: In this study we investigate whether dystrophic intrinsic laryngeal muscles (ILM) from aged mdx mice show alterations in dystrophin-glycoprotein complex (DGC) components.Immunofluorescence and immunoblotting analyses of beta-sarcoglycan, beta-dystroglycan, and utrophin showed that aged ILM had a similar pattern of changes in aged affected muscles (diaphragm and limb), suggesting that aging leads to changes in utrophin and DGC proteins in dystrophic ILM that cannot be correlated with their protection from dystrophic change.
Subject: Aging
Animals
Dystroglycans
Dystrophin
Glycoproteins
Laryngeal Muscles
Male
Mice
Mice, Inbred C57bl
Mice, Inbred Mdx
Muscular Dystrophy, Animal
Sarcoglycans
Utrophin
Rights: fechado
Identifier DOI: 10.1002/mus.22235
Address: http://www.ncbi.nlm.nih.gov/pubmed/22102469
Date Issue: 2011
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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