Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199687
Type: Artigo de periódico
Title: Polymers Containing Hydroxamate Groups: Nanoreactors For Hydrolysis Of Phosphoryl Esters.
Author: Mello, Renata S
Orth, Elisa S
Loh, Watson
Fiedler, Haidi D
Nome, Faruk
Abstract: A polyhydroxamicalkanoate (PHA) polymer containing the functional groups hydroxamic acid and carboxylic acid with the ability to accelerate dephosphorylation reactions is proposed. The methodology used to prepare this polymer favored the position of the two functional groups next to each other, which allows for the cooperativity between these groups. This cooperative effect has an important role when one wants to mimic enzymes. The catalytic effect promoted by the polymer was evaluated on the cleavage of the bis(2,4-dinitrophenyl) phosphate (BDNPP) and diethyl 2,4-dinitrophenyl phosphate (DEDNPP) esters. Indeed, PHA was very efficient and promiscuous because it increased the rate of both reactions by a factor of up to 10(6)-fold. Isothermal titration calorimetry (ITC) experiments showed that the presence of PHA aids the formation of cetyltrimethylammonium bromide (CTABr) micelles. Thus, the effect of the cationic surfactant CTABr on the dephosphorylation of BDNPP by PHA was also investigated, and it was observed that, when CTABr is added to PHA, the reaction is ca. 15-fold faster compared to the reaction when only PHA is present.
Subject: Calorimetry
Carboxylic Acids
Catalysis
Cetrimonium Compounds
Hydrogen-ion Concentration
Hydrolysis
Hydroxamic Acids
Kinetics
Mass Spectrometry
Micelles
Molecular Mimicry
Nanotechnology
Organophosphates
Phosphoric Monoester Hydrolases
Polymers
Potentiometry
Substrate Specificity
Surface-active Agents
Rights: fechado
Identifier DOI: 10.1021/la203437j
Address: http://www.ncbi.nlm.nih.gov/pubmed/22053995
Date Issue: 2011
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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