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Type: Artigo de periódico
Title: Multivariate Control Charts Based On Net Analyte Signal (nas) And Raman Spectroscopy For Quality Control Of Carbamazepine.
Author: Rocha, Werickson Fortunato de Carvalho
Poppi, Ronei Jesus
Abstract: Raman spectroscopy and control charts based on the net analyte signal (NAS) were applied to polymorphic characterization of carbamazepine. Carbamazepine presents four polymorphic forms: I-IV (dihydrate). X-ray powder diffraction was used as a reference technique. The control charts were built generating three charts: the NAS chart that corresponds to the analyte of interest (form III in this case), the interference chart that corresponds to the contribution of other compounds in the sample and the residual chart that corresponds to nonsystematic variations. For each chart, statistical limits were developed using samples within the quality specifications. It was possible to identify the different polymorphic forms of carbamazepine present in pharmaceutical formulations. Thus, an alternative method for the quality monitoring of the carbamazepine polymorphic forms after the crystallization process is presented.
Subject: Analgesics, Non-narcotic
Multivariate Analysis
Powder Diffraction
Quality Control
Spectrum Analysis, Raman
X-ray Diffraction
Citation: Analytica Chimica Acta. v. 705, n. 1-2, p. 35-40, 2011-Oct.
Rights: fechado
Identifier DOI: 10.1016/j.aca.2011.03.024
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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