Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199635
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleOct4 Immunohistochemistry May Be Necessary To Identify The Real Risk Of Gonadal Tumors In Patients With Turner Syndrome And Y Chromosome Sequences.pt_BR
dc.contributor.authorBarros, B Apt_BR
dc.contributor.authorMoraes, S Gpt_BR
dc.contributor.authorCoeli, F Bpt_BR
dc.contributor.authorAssumpção, J Gpt_BR
dc.contributor.authorDe Mello, M Ppt_BR
dc.contributor.authorMaciel-Guerra, A Tpt_BR
dc.contributor.authorCarvalho, A Bpt_BR
dc.contributor.authorViguetti-Campos, Npt_BR
dc.contributor.authorVieira, T A Ppt_BR
dc.contributor.authorAmstalden, E M Ipt_BR
dc.contributor.authorAndrade, J G Rpt_BR
dc.contributor.authorEsquiaveto-Aun, A Mpt_BR
dc.contributor.authorMarques-de-Faria, A Ppt_BR
dc.contributor.authorD'Souza-Li, L F Rpt_BR
dc.contributor.authorLemos-Marini, S H Vpt_BR
dc.contributor.authorGuerra, Gpt_BR
unicamp.authorB A Barros, Department of Pediatrics, Faculty of Medical Sciences (FCM), University of Campinas (UNICAMP), Campinas, SP 13083-100, Brazil.pt_BR
unicamp.author.externalS G Moraes,pt
unicamp.author.externalF B Coeli,pt
unicamp.author.externalJ G Assumpção,pt
unicamp.author.externalM P De Mello,pt
unicamp.author.externalA T Maciel-Guerra,pt
unicamp.author.externalA B Carvalho,pt
unicamp.author.externalN Viguetti-Campos,pt
unicamp.author.externalT A P Vieira,pt
unicamp.author.externalE M I Amstalden,pt
unicamp.author.externalJ G R Andrade,pt
unicamp.author.externalA M Esquiaveto-Aun,pt
unicamp.author.externalA P Marques-de-Faria,pt
unicamp.author.externalL F R D'Souza-Li,pt
unicamp.author.externalS H V Lemos-Marini,pt
unicamp.author.externalG Guerra,pt
dc.subjectAdolescentpt_BR
dc.subjectCarcinoma In Situpt_BR
dc.subjectChildpt_BR
dc.subjectChromosomes, Human, Ypt_BR
dc.subjectFemalept_BR
dc.subjectGonadoblastomapt_BR
dc.subjectHumanspt_BR
dc.subjectImmunohistochemistrypt_BR
dc.subjectOctamer Transcription Factor-3pt_BR
dc.subjectRisk Assessmentpt_BR
dc.subjectTurner Syndromept_BR
dc.description.abstractThe aim of this study was to investigate the frequency of gonadal tumors among patients with Turner syndrome (TS) carrying Y-derivative sequences in their chromosomal constitution. Six out of 260 patients with TS were selected based on mosaicism of the entire Y chromosome; 10 were included because Y-derivative sequences have been detected by PCR with specific oligonucleotides (sex-determining region on the Y, testis specific-protein, Y and DYZ3) and further confirmed by FISH. The 16 patients were subjected to bilateral gonadectomy at ages varying from 8.7 to 18.2 years. Both histopathological investigation with hematoxylin and eosin (H&E) and immunohistochemical analysis with anti-octamer-binding transcription factor 4 (OCT4) antibody were performed. Gonadal neoplasia was not detected in any of the 32 gonads evaluated by H&E; however, four gonads (12%) from three patients (19%) had positive OCT4 staining in 50-80% of nuclei, suggesting the existence of germ cell tumors (gonadoblastoma or in situ carcinoma). Evaluation of the real risk of development of gonadal tumors in TS patients with Y-derivative sequences in their chromosomal constitution may require a specific histopathological study, such as immunohistochemistry with OCT4.en
dc.relation.ispartofHuman Reproduction (oxford, England)pt_BR
dc.relation.ispartofabbreviationHum. Reprod.pt_BR
dc.date.issued2011-Decpt_BR
dc.identifier.citationHuman Reproduction (oxford, England). v. 26, n. 12, p. 3450-5, 2011-Dec.pt_BR
dc.language.isoengpt_BR
dc.description.volume26pt_BR
dc.description.firstpage3450-5pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1460-2350pt_BR
dc.identifier.doi10.1093/humrep/der310pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21930534pt_BR
dc.date.available2015-11-27T13:21:53Z-
dc.date.accessioned2015-11-27T13:21:53Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:21:53Z (GMT). No. of bitstreams: 1 pmed_21930534.pdf: 201142 bytes, checksum: 3772fc9edf2a9f4c7ca0869a3dba315b (MD5) Previous issue date: 2011en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199635-
dc.identifier.idPubmed21930534pt_BR
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_21930534.pdf196.43 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.