Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/1996
Type: Artigo de periódico
Title: Primary nasal mucosal melanoma in Brazil: clinicopathologic and immunohistochemical study of 12 patients
Author: Benevenuto de Andrade, Bruno Augusto
Pina, Alicia Rumayor
Leon, Jorge Esquiche
de Almeida, Oslei Paes
Altemani, Albina
Abstract: Primary nasal melanoma is a rare tumor of unknown etiopathogenesis that occurs in adult and elderly patients usually diagnosed at advanced stages. The aim of this study was to analyze the clinicopathologic and immunohistochemical characteristics of 12 cases of primary nasal melanomas in Brazil. Twelve cases of primary nasal melanoma were analyzed histologically and by immunohistochemistry using the antibodies S-100 protein, HMB-45, Melan-A, CD63 (NKI/C3), CD68/KP1, fatty acid synthase (FASN), and Ki-67. The mean age of the patients was 60 years, and 7 of 12 patients were men. Microscopically, 10 cases presented level ill of invasion; 4 were amelanotic; and in 7, cells were epithelioid. S-100 protein and FASN were positive in all cases, whereas 9, 8, 7, and 6 cases were positive for HMB-45, Melan-A, CD63 (NKI/C3), and CD68/KP1, respectively. Ki-67 labeling index ranged from 11.45% to 28.5% of positive cells. S-100 protein is more frequently expressed in nasal melanomas than in HMB-45, Melan-A, CD63 (NKI/C3), and CD68/KP1. FASN seems to be involved in the pathogenesis of nasal melanomas, and also, it can be helpful to confirm the diagnosis. (C) 2012 Elsevier Inc. All rights reserved.
Subject: Nasal melanoma
Histopathology
Immunohistochemistry
Diagnosis
Editor: Elsevier
Rights: fechado
Identifier DOI: 10.1016/j.anndiagpath.2012.02.001
Date Issue: 2012
Appears in Collections:FOP - Artigos e Outros Documentos

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