Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199580
Type: Artigo de periódico
Title: Cytotoxicity Of Active Ingredients Extracted From Plants Of The Brazilian Cerrado"."
Author: Soares, Veronica C G
Bonacorsi, Cibele
Andrela, Alana L B
Bortoloti, Lígia V
de Campos, Stepheny C
Fagundes, Fábio H R
Piovani, Márcio
Cotrim, Camila A
Vilegas, Wagner
Toyama, Marcos H
Abstract: Cytotoxicity assays are needed for the screening of natural products with potential anti-inflammatory. The purpose of this study was to compare the basal cytotoxicity of active ingredients extracted from plants of the Brazilian cerrado. The viability was assayed with the neutral red uptake assay in Mac Coy cells after 24h of exposition. The dose evaluated was 50 microg/microL. The test substances were: cinnamic acid, p-coumaric acid, chlorogenic acid, syringic acid, vannilic acid, homogentisic acid, scandenin, palustric acid, diosgenin, cabraleone. Studies of cytotoxicity demonstrated that all active compounds evaluated have low toxicity in vitro. The substances showed cell viability above 60% for the concentration used. However, the cinnamic acid, sacandenin and palustric acid showed highest toxicity with a 50% reduction in cell viability for the dose of 50 microg/microL. Cytotoxic screening results are useful to estimate the best concentrations of those compounds with potential anti-inflammatory without their cause cell death.
Subject: Animals
Brazil
Cell Line
Cell Survival
Cytotoxins
Mice
Plant Extracts
Plants
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/21834238
Date Issue: 2011
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.