Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Simultaneous Monitoring Of Cmv And Human Herpesvirus 6 Infections And Diseases In Liver Transplant Patients: One-year Follow-up.
Author: Costa, Fernanda Aparecida
Soki, Marcelo Naoki
Andrade, Paula Durante
Bonon, Sandra Helena Alves
Thomasini, Ronaldo Luis
Sampaio, Ana Maria
Ramos, Marcelo de Carvalho
Rossi, Claudio Lúcio
Cavalcanti, Teresa Cristina
Boin, Ilka de Fatima
Leonard, Marília
Leonard, Luiz Sérgio
Stucchi, Raquel Bello
Costa, Sandra Cecília Botelho
Abstract: The aim of this study was to simultaneously monitoring cytomegalovirus and human herpesvirus 6 active infections using nested-polymerase chain reaction and, together with clinical findings, follow the clinical status of patients undergoing liver transplant. The human β-herpesviruses, including cytomegalovirus and human herpesvirus 6, are ubiquitous among human populations. Active infections of human herpesvirus 6 and cytomegalovirus are common after liver transplantation, possibly induced and facilitated by allograft rejection and immunosuppressive therapy. Both viruses affect the success of the transplant procedure. Thirty patients submitted to liver transplant at the Liver Transplant Unit, at the Gastro Center, State University of Campinas, SP, Brazil, were studied prospectively from six months to one year, nested-polymerase chain reaction for cytomegalovirus and human herpesvirus 6 DNA detections. Two or more consecutive positive nested-polymerase chain reaction were considered indicative of active infection. Active infection by cytomegalovirus was detected in 13/30 (43.3%) patients, median time to first cytomegalovirus detection was 29 days after transplantation (range: 0-99 days). Active infection by human herpesvirus 6 was detected in 12/30 (40%) patients, median time to first human herpesvirus 6 detection was 23.5 days after transplantation (range: 0-273 days). The time-related appearance of each virus was not statistically different (p = 0.49). Rejection of the transplanted liver was observed in 16.7% (5/30) of the patients. The present analysis showed that human herpesvirus 6 and/or cytomegalovirus active infections were frequent in liver transplant recipients at our center. Few patients remain free of betaherpesviruses after liver transplantation. Most patients presenting active infection with more than one virus were infected sequentially and not concurrently. Nested-polymerase chain reaction can be considered of limited value for clinically monitoring cytomegalovirus and human herpesvirus 6.
Subject: Cytomegalovirus
Cytomegalovirus Infections
Dna, Viral
Follow-up Studies
Graft Rejection
Herpesvirus 6, Human
Liver Transplantation
Polymerase Chain Reaction
Postoperative Complications
Prospective Studies
Roseolovirus Infections
Statistics, Nonparametric
Time Factors
Citation: Clinics (são Paulo, Brazil). v. 66, n. 6, p. 949-53, 2011.
Rights: aberto
Identifier DOI: 
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_21808857.pdf146.77 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.