Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199546
Type: Artigo de periódico
Title: Lessons From The Epidemiological Surveillance Program, During The Influenza A (h1n1) Virus Epidemic, In A Reference University Hospital Of Southeastern Brazil.
Author: Moretti, Maria Luiza
Sinkoc, Verônica
Cardoso, Luis Gustavo de Oliveira
Camargo, Gema Jesus de
Bachur, Luis Felipe
Hofling, Christian Cruz
Angerami, Rodrigo
Trabasso, Plínio
Garcia, Márcia Teixeira
Resende, Mariângela Ribeiro
Abstract: The case definition of influenza-like illness (ILI) is a powerful epidemiological tool during influenza epidemics. A prospective cohort study was conducted to evaluate the impact of two definitions used as epidemiological tools, in adults and children, during the influenza A H1N1 epidemic. Patients were included if they had upper respiratory samples tested for influenza by real-time reverse transcriptase polymerase chain reaction during two periods, using the ILI definition (coughing + temperature ≤ 38ºC) in period 1, and the definition of severe acute respiratory infection (ARS) (coughing + temperature ≤ 38ºC and dyspnoea) in period 2. The study included 366 adults and 147 children, covering 243 cases of ILI and 270 cases of ARS. Laboratory confirmed cases of influenza were higher in adults (50%) than in children (21.6%) ( p < 0.0001) and influenza infection was more prevalent in the ILI definition (53%) than ARS (24.4%) (p < 0.0001). Adults reported more chills and myalgia than children (p = 0.0001). Oseltamivir was administered in 58% and 46% of adults and children with influenza A H1N1, respectively. The influenza A H1N1 case fatality rate was 7% in adults and 8.3% in children. The mean time from onset of illness until antiviral administration was 4 days. The modification of ILI to ARS definition resulted in less accuracy in influenza diagnosis and did not improve the appropriate time and use of antiviral medication.
Subject: Acute Disease
Adolescent
Adult
Aged
Antiviral Agents
Brazil
Child
Child, Preschool
Cohort Studies
Epidemics
Female
Hospitals, University
Humans
Influenza A Virus, H1n1 Subtype
Influenza, Human
Male
Middle Aged
Oseltamivir
Population Surveillance
Prospective Studies
Reverse Transcriptase Polymerase Chain Reaction
Seasons
Young Adult
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/21789355
Date Issue: -1-Uns- -1
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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