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Type: Artigo de periódico
Title: Keeping An Eye On Myocilin: A Complex Molecule Associated With Primary Open-angle Glaucoma Susceptibility.
Author: Menaa, Farid
Braghini, Carolina Ayumi
Vasconcellos, Jose Paulo Cabral De
Menaa, Bouzid
Costa, Vital Paulino
Figueiredo, Eugênio Santana De
Melo, Monica Barbosa De
Abstract: MYOC encodes a secretary glycoprotein of 504 amino acids named myocilin. MYOC is the first gene to be linked to juvenile open-angle glaucoma (JOAG) and some forms of adult-onset primary open-angle glaucoma (POAG). The gene was identified as an up-regulated molecule in cultured trabecular meshwork (TM) cells after treatment with dexamethasone and was originally referred to as trabecular meshwork-inducible glucocorticoid response (TIGR). Elevated intraocular pressure (IOP), due to decreased aqueous outflow, is the strongest known risk factor for POAG. Increasing evidence showed that the modulation of the wild-type (wt) myocilin protein expression is not causative of glaucoma while some misfolded and self-assembly aggregates of mutated myocilin may be associated with POAG in related or unrelated populations. The etiology of the disease remains unclear. Consequently, a better understanding of the molecular mechanisms underlying POAG is required to obtain early diagnosis, avoid potential disease progression, and develop new therapeutic strategies. In the present study, we review and discuss the most relevant studies regarding structural characterizations, expressions, molecular interactions, putative functions of MYOC gene and/or its corresponding protein in POAG etiology.
Subject: Amino Acid Sequence
Cytoskeletal Proteins
Eye Proteins
Glaucoma, Open-angle
Molecular Sequence Data
Protein Folding
Sequence Homology, Amino Acid
Citation: Molecules (basel, Switzerland). v. 16, n. 7, p. 5402-21, 2011.
Rights: aberto
Identifier DOI: 10.3390/molecules16075402
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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