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Type: Artigo de periódico
Title: In Vitro Evaluation Of The Type Of Interaction Obtained By The Combination Of Terbinafine And Itraconazole, Voriconazole, Or Amphotericin B Against Dematiaceous Molds.
Author: Biancalana, Fernanda Simas Corrêa
Lyra, Luzia
Schreiber, Angélica Zaninelli
Abstract: In vitro associations using the checkerboard microdilution method indicated lower MIC ranges and MIC median values for each drug (terbinafine, itraconazole, voriconazole, and amphotericin B) in association than those obtained for each single drug. Fractional inhibitory concentration index (FIC) results showed 100% synergism in the association of terbinafine with voriconazole, 96.5% in the association of terbinafine with amphotericin B, and 75.9% in the association of terbinafine with itraconazole. Drug combinations may be useful for treatment of dematiaceous mold infections as an alternative treatment to enhance the effectiveness of each drug.
Subject: Amphotericin B
Antifungal Agents
Drug Interactions
Microbial Sensitivity Tests
Citation: Antimicrobial Agents And Chemotherapy. v. 55, n. 9, p. 4485-7, 2011-Sep.
Rights: aberto
Identifier DOI: 10.1128/AAC.01015-10
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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