Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199479
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleCharacterization Of The Urinary Bladder Dysfunction In Renovascular Hypertensive Rats.pt_BR
dc.contributor.authorRamos-Filho, Antonio C Spt_BR
dc.contributor.authorMónica, Fabíola Z Tpt_BR
dc.contributor.authorFranco-Penteado, Carla Fpt_BR
dc.contributor.authorRojas-Moscoso, Julio Apt_BR
dc.contributor.authorBáu, Fernando Rpt_BR
dc.contributor.authorSchenka, André Apt_BR
dc.contributor.authorDe Nucci, Gilbertopt_BR
dc.contributor.authorAntunes, Edsonpt_BR
unicamp.authorAntonio C S Ramos-Filho, Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.pt_BR
unicamp.author.externalFabíola Z T Mónica,pt
unicamp.author.externalCarla F Franco-Penteado,pt
unicamp.author.externalJulio A Rojas-Moscoso,pt
unicamp.author.externalFernando R Báu,pt
unicamp.author.externalAndré A Schenka,pt
unicamp.author.externalGilberto De Nucci,pt
unicamp.author.externalEdson Antunes,pt
dc.subjectAdrenergic Beta-agonistspt_BR
dc.subjectAnimalspt_BR
dc.subjectCholinergic Agonistspt_BR
dc.subjectCyclic Amppt_BR
dc.subjectDisease Models, Animalpt_BR
dc.subjectDose-response Relationship, Drugpt_BR
dc.subjectElectric Stimulationpt_BR
dc.subjectHypertension, Renovascularpt_BR
dc.subjectMalept_BR
dc.subjectMuscle Contractionpt_BR
dc.subjectMuscle Relaxationpt_BR
dc.subjectMuscle, Smoothpt_BR
dc.subjectNeuromuscular Agentspt_BR
dc.subjectProtein Kinase Inhibitorspt_BR
dc.subjectPurinergic P2x Receptor Agonistspt_BR
dc.subjectRna, Messengerpt_BR
dc.subjectRatspt_BR
dc.subjectRats, Wistarpt_BR
dc.subjectReceptor, Muscarinic M3pt_BR
dc.subjectSignal Transductionpt_BR
dc.subjectTime Factorspt_BR
dc.subjectUp-regulationpt_BR
dc.subjectUrinary Bladderpt_BR
dc.subjectUrinary Bladder Diseasespt_BR
dc.subjectUrodynamicspt_BR
dc.subjectRho-associated Kinasespt_BR
dc.description.abstractAssociation between arterial hypertension and urinary bladder dysfunction has been reported in humans and spontaneously hypertensive rats. However, no study exists evaluating the bladder dysfunction in conditions of renovascular hypertension. The purpose of this study was to characterize the bladder dysfunction in two kidney-one clip (2K-1C) hypertensive rats. A silver clip was placed around the renal artery of male Wistar rats. After 8 weeks, cystometric study, concentration-response curves to contractile and relaxant agents, frequency-dependent contractions, histomorphometry, muscarinic M(2) /M(3) mRNA expression and cyclic AMP measurements were performed. 2K-1C rats showed enhanced bladder volume, wall thickness and smooth muscle density. 2K-1C rats also exhibited increases in bladder capacity and non-void contractions, and decreases in the inter-contraction intervals. In isolated detrusor smooth muscle (DSM), contractions to carbachol and electrical-field stimulation (EFS) were significantly greater in 2K-1C rats. The Rho-kinase inhibitor Y27632 (10 µM) significantly reduced the carbachol-induced contractions in SHAM and 2K-1C rats, but DSM remained overactive in 2K-1C rats in presence of Y27632. Concentration-dependent contractions to the P2X receptor agonist α,β-methylene ATP, KCl and extracellular Ca(2+) did not change between SHAM and 2K-1C groups. In 2K-1C rats, isoproterenol, metaproterenol and BRL 37-344 (non-selective, β(2) - and β(3) -selective adrenoceptor agonists, respectively) produced significantly lower relaxations and decreased cAMP levels, whereas relaxant responses to sodium nitroprusside and BAY 41-2272 remained unchanged. Muscarinic M(3) mRNA expression receptors were higher in 2K-1C group. Renovascular hypertensive rats exhibit bladder dysfunction that involves tissue remodeling and enhanced muscarinic M(3) -mediated contractions associated with reduced β-adrenoceptor-mediated signal transduction.en
dc.relation.ispartofNeurourology And Urodynamicspt_BR
dc.relation.ispartofabbreviationNeurourol. Urodyn.pt_BR
dc.date.issued2011-Seppt_BR
dc.identifier.citationNeurourology And Urodynamics. v. 30, n. 7, p. 1392-402, 2011-Sep.pt_BR
dc.language.isoengpt_BR
dc.description.volume30pt_BR
dc.description.firstpage1392-402pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright © 2011 Wiley-Liss, Inc.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1520-6777pt_BR
dc.identifier.doi10.1002/nau.21074pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21661033pt_BR
dc.date.available2015-11-27T13:21:32Z-
dc.date.accessioned2015-11-27T13:21:32Z-
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dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199479-
dc.identifier.idPubmed21661033pt_BR
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