Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199443
Type: Artigo de periódico
Title: Oral Administration Of Aloe Vera And Honey Reduces Walker Tumour Growth By Decreasing Cell Proliferation And Increasing Apoptosis In Tumour Tissue.
Author: Tomasin, Rebeka
Gomes-Marcondes, Maria Cristina Cintra
Abstract: Cancer is diagnosed in approximately 11 million people and is responsible for almost 8 million deaths worldwide every year. Research in cancer control has shown the importance of co-adjuvant therapies. Aloe vera may reduce tumour mass and metastasis rates, while honey may inhibit tumour growth. This study verified the influence of Aloe vera and honey on tumour growth and in the apoptosis process by assessing tumour size, the cell proliferation rate (Ki67-LI) and Bax/Bcl-2 expression at 7, 14 and 20 days after Walker 256 carcinoma implant in Wistar rats distributed into two groups: the WA group - tumour-bearing rats that received a gavage with a 670 µL/kg dose of Aloe vera and honey solution daily, and the CW group - tumour-bearing rats which received only a 0.9% NaCl solution. The effect of Aloe vera and honey against tumour growth was observed through a decrease in relative weight (%) and Ki67-LI in tumours from the WA group compared with those from the CW group. The Bax/Bcl-2 ratio increased in tumours from the WA group at all tested timepoints. These data suggest Aloe vera and honey can modulate tumour growth by reducing cell proliferation and increasing apoptosis susceptibility.
Subject: Administration, Oral
Aloe
Animals
Apoptosis
Carcinoma 256, Walker
Cell Proliferation
Honey
Male
Rats
Rats, Wistar
Rights: fechado
Identifier DOI: 10.1002/ptr.3293
Address: http://www.ncbi.nlm.nih.gov/pubmed/20839215
Date Issue: 2011
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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