Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199432
Type: Artigo de periódico
Title: Acute And Chronic Effects Of Exercise On Inflammatory Markers And B-type Natriuretic Peptide In Patients With Coronary Artery Disease.
Author: Lara Fernandes, Juliano
Serrano, Carlos Vicente
Toledo, Flavia
Hunziker, Maria Fernanda
Zamperini, Augusto
Teo, Fabio H
Oliveira, Romulo T
Blotta, Maria Heloisa
Rondon, Maria Urbana
Negrão, Carlos Eduardo
Abstract: Few studies have prospectively addressed the effects of exercise in the inflammatory activity of patients with coronary artery disease (CAD). We sought to evaluate the consequences of an acute bout of exercise on inflammatory markers and BNP in untrained CAD patients before and after randomization to a training program. 34 CAD patients underwent a 50-min acute exercise session on a cycle-ergometer at 65% peak oxygen uptake before and after blood sampling. They were then randomized to a 4-month chronic exercise program (15 patients) or general lifestyle recommendations (19 patients), undergoing a new acute session of exercise after that. In the overall population, acute exercise caused a significant increase in C-reactive protein [CRP; 1.79 (4.49) vs. 1.94 (4.89) mg/L, P < 0.001], monokine induced by interferon-γ [Mig; 351 (324) vs. 373 (330) pg/mL, P = 0.027] and vascular adhesion molecule-1 [VCAM-1; 226 (82) vs. 252 (110) pg/mL, P = 0.02]. After 4-months, in exercise-trained patients, there was a significant decrease in the inflammatory response provoked by the acute exercise compared to patients in the control group reflected by a significant decrease in the differences between rest and post-exercise levels of CRP [-0.29 (0.84) mg/L vs. -0.11 (0.21) mg/L, P = 0.05]. Resting BNP was also significantly lower in exercise-trained patients when compared to untrained controls [15.6 (16.2) vs. 9.7 (11.4) pg/mL, P = 0.04 and 19.2 (27.8) vs. 23.2 (27.5) pg/mL, P = 0.76; respectively]. Chronic exercise training might partially reverse the inflammatory response caused by acute exercise in CAD patients. These results suggest that regular exercise is an important nonpharmacological strategy to the improvement in inflammation in CAD patients.
Subject: Acute Disease
Adult
Aged
Biological Markers
Chronic Disease
Coronary Artery Disease
Cytokines
Exercise
Exercise Test
Female
Humans
Inflammation
Male
Middle Aged
Natriuretic Peptide, Brain
Rights: fechado
Identifier DOI: 10.1007/s00392-010-0215-x
Address: http://www.ncbi.nlm.nih.gov/pubmed/20835904
Date Issue: 2011
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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