Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199412
Type: Artigo de periódico
Title: Genetic Profile Of Adenoid Cystic Carcinomas (acc) With High-grade Transformation Versus Solid Type.
Author: Costa, Ana Flávia
Altemani, Albina
Vékony, Hedy
Bloemena, Elisabeth
Fresno, Florentino
Suárez, Carlos
Llorente, José Luis
Hermsen, Mario
Abstract: ACC can occasionally undergo dedifferentiation also referred to as high-grade transformation (ACC-HGT). However, ACC-HGT can also undergo transformation to adenocarcinomas which are not poorly differentiated. ACC-HGT is generally considered to be an aggressive variant of ACC, even more than solid ACC. This study was aimed to describe the genetic changes of ACC-HGT in relation to clinico-pathological features, and to compare results to solid ACC. Genome wide DNA copy number changes were analyzed by microarray CGH in ACC-HGT, four with transformation into moderately differentiated adenocarcinoma (MDA) and two into poorly differentiated carcinoma (PDC), and five solid ACC. In addition, Ki67 index and p53 immunopositivity was assessed. ACC-HGT carried fewer copy number changes compared to solid ACC. Two ACC-HGT cases harboured a breakpoint at 6q23, near the cMYB oncogene. The complexity of the genomic profile concurred with the clinical course of the patient. Among the ACC-HGT, p53 positivity significantly increased from the conventional to the transformed (both MDA and PDC) component. ACC-HGT may not necessarily reflect a more advanced stage of tumor progression, but rather a transformation to another histological form in which the poorly differentiated forms (PDC) presents a genetic complexity similar to the solid ACC.
Subject: Actins
Adenocarcinoma
Adult
Aged
Carcinoma, Adenoid Cystic
Cell Differentiation
Cell Transformation, Neoplastic
Chromosomes, Human, Pair 6
Comparative Genomic Hybridization
Dna Copy Number Variations
Female
Follow-up Studies
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Ki-67 Antigen
Male
Middle Aged
Neoplasm Grading
Oligonucleotide Array Sequence Analysis
Rights: fechado
Identifier DOI: 10.1007/s13402-011-0037-5
Address: http://www.ncbi.nlm.nih.gov/pubmed/21541734
Date Issue: 2011
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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