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Type: Artigo de periódico
Title: Pharmacogenetic Implications Of The Enos Polymorphisms For Cardiovascular Action Drugs.
Author: Silva, Pâmela Souza
Lacchini, Riccardo
Gomes, Valéria de Aguiar
Tanus-Santos, José Eduardo
Abstract: The pharmacogenetics is one of the most promising fields of medicine. The conclusion of the Genome Project allowed this field to start discovering complex factors modulating the response to drugs, and new technologies are close a great expansion of the area. The cardiovascular diseases are currently among the major causes of hospitalizations and death, and have been the target of a large part of genetic studies of complex diseases. Parallel to the susceptibility to disease markers identification, it is necessary to investigate how different genetic profiles can change the responses to the currently used drugs. The biological system that controls the endothelial production of the nitric oxide has been one of the greatest targets in the pharmacological responses to the drugs used in the cardiovascular diseases therapy. This review aims at approaching the current knowledge on interaction among the genetic variations of eNOS and the pharmacological responses to the drugs used in the cardiovascular system.
Subject: Cardiovascular Agents
Cardiovascular Diseases
Nitric Oxide
Nitric Oxide Synthase Type Iii
Polymorphism, Genetic
Rights: aberto
Identifier DOI: 
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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