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Type: Artigo de periódico
Title: In Vitro And In Vivo Anticancer Activity Of Extracts, Fractions, And Eupomatenoid-5 Obtained From Piper Regnellii Leaves.
Author: Longato, Giovanna Barbarini
Rizzo, Larissa Yokota
Sousa, Ilza Maria de Oliveira
Tinti, Sirlene Valério
Possenti, Ana
Figueira, Glyn Mara
Ruiz, Ana Lúcia Tasca Gois
Foglio, Mary Ann
de Carvalho, João Ernesto
Abstract: Despite numerous studies with the Piper genus, there are no previous results reporting in vitro or in vivo Piper regnellii (Miq.) C. DC. var. regnellii anticancer activity. The aim of this study was to investigate P. regnellii in vitro and in vivo anticancer activity and further identify its active compounds. In vitro antiproliferative activity was evaluated in 8 human cancer cell lines: melanoma (UACC-62), breast (MCF7), kidney (786-0), lung (NCI-H460), prostate (PC-3), ovary (OVCAR-3), colon (HT29), and leukemia (K-562). Total growth inhibition (TGI) values were chosen to measure antiproliferative activity. Among the cell lines evaluated, eupomatenoid-5 demonstrated better in vitro antiproliferative activity towards prostate, ovary, kidney, and breast cancer cell lines. In vivo studies were carried out with Ehrlich solid tumor on Balb/C mice treated with 100, 300, and 1000 mg/kg of P. regnellii leaves dichloromethane crude extract (DCE), with 30 and 100 mg/kg of the active fraction (FRB), and with 30 mg/kg of eupomatenoid-5. The i. p. administration of DCE, FRB, and eupomatenoid-5 significantly inhibited tumor progression in comparison to control mice (saline). Therefore, this study showed that neolignans of Piper regnellii have promising anticancer activity. Further studies will be undertaken to determine the mechanism of action and toxicity of these compounds.
Subject: Animals
Antineoplastic Agents
Carcinoma, Ehrlich Tumor
Cell Line, Tumor
Mice, Inbred Balb C
Plant Extracts
Plant Leaves
Rights: aberto
Identifier DOI: 10.1055/s-0030-1270889
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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