Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199316
Type: Artigo de periódico
Title: Altered Hypothalamic Function In Diet-induced Obesity.
Author: Velloso, L A
Schwartz, M W
Abstract: Energy homeostasis involves a complex network of hypothalamic and extra-hypothalamic neurons that transduce hormonal, nutrient and neuronal signals into responses that ultimately match caloric intake to energy expenditure and thereby promote stability of body fat stores. Growing evidence suggests that rather than reflecting a failure to regulate caloric intake, common forms of obesity involve fundamental changes to this homeostatic system that favor the defense of an elevated level of body adiposity. This article reviews emerging evidence that during high-fat feeding, obesity pathogenesis involves fundamental alteration of hypothalamic systems that regulate food intake and energy expenditure.
Subject: Animals
Energy Intake
Energy Metabolism
Homeostasis
Hypothalamus
Leptin
Mice
Obesity
Signal Transduction
Rights: fechado
Identifier DOI: 10.1038/ijo.2011.56
Address: http://www.ncbi.nlm.nih.gov/pubmed/21386802
Date Issue: 2011
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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