Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199306
Type: Artigo de periódico
Title: Inhibition Of Tumor Growth By Quercetin With Increase Of Survival And Prevention Of Cachexia In Walker 256 Tumor-bearing Rats.
Author: Camargo, Camila A
da Silva, Maria Eleonora F
da Silva, Rodrigo A
Justo, Giselle Z
Gomes-Marcondes, Maria Cristina C
Aoyama, Hiroshi
Abstract: Quercetin, a flavonoid abundantly present in fruit, vegetables, wine and tea, has revealed several properties such as antioxidant, antiproliferative and anticancer. Cachexia is a poorly understood syndrome present in already compromised cancer patients, decreasing the quality of life and increasing mortality. Many studies have been performed in an attempt to discover an effective treatment for cachexia, but none of the tested therapies has fulfilled expectations. The objective of the present study was to analyze the effect of quercetin in the therapeutic treatment of cachexia and reversion of tumor growth in rats bearing Walker 256 carcinosarcoma (W256). Rats bearing W256 were treated daily with I.P. quercetin injections, at different doses (10, 15, 25 and 35 mg/kg). The results show that 10 mg/kg quercetin inhibited tumor growth by about 50% (ED(50)) when compared with controls (CTR). Moreover, two animals of this group presented complete tumor regression. Matrix metalloproteinase-2 (MMP-2) activity and vascular endothelial growth factor (VEGF) expression decreased in rats bearing W256 treated with 10 mg/kg quercetin when compared with CTR. Thus, the inhibition of tumor growth, survival increase, decrease of MMP-2 and VEGF levels and reduction of cachexia in animals treated with quercetin strongly support the anticancer function of this flavonoid.
Subject: Animals
Antineoplastic Agents
Cachexia
Carcinoma 256, Walker
Liver
Male
Matrix Metalloproteinase 2
Quercetin
Rats
Rats, Wistar
Vascular Endothelial Growth Factor A
Citation: Biochemical And Biophysical Research Communications. v. 406, n. 4, p. 638-42, 2011-Mar.
Rights: fechado
Identifier DOI: 10.1016/j.bbrc.2011.02.111
Address: http://www.ncbi.nlm.nih.gov/pubmed/21362404
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_21362404.pdf348.83 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.