Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199289
Type: Artigo de periódico
Title: Protective Effect Of Guaraná (paullinia Cupana Var. Sorbilis) Pre-treatment On Cadmium-induced Damages In Adult Wistar Testis.
Author: Leite, Rodrigo Paula
Wada, Ronaldo Seichi
Monteiro, Juliana Castro
Predes, Fabrícia Souza
Dolder, Heidi
Abstract: Guaraná (Paullinia cupana) is an Amazonian plant. Its antioxidant potential was demonstrated to be due to the high polyphenol concentration. On the other hand, one of the mechanisms underlying cadmium-induced cellular damage is free radical mediated, resulting in increased oxidative processes. This study investigated P. cupana's potential to attenuate cadmium-induced damages in Wistar rat testis. Adult male Wistar rats were either pre-treated with 2 mg/g body weight (BW) of powdered P. cupana seed during 56 days and/or injected with cadmium chloride at a dose of 1.15 mg/kg BW. After cadmium exposition (48 h), testes samples were evaluated by histological and stereological analyses. Both groups exposed to cadmium presented evident morphological alterations relative to control animals. A few rodents showed massive cell death in the seminiferous epithelium and intertubular space, indicating that some animals are more sensitive to cadmium. Despite the alterations observed in both groups, pre-treatment with P. cupana was effective in attenuating morphological changes in Leydig cells, as well as reducing inflammatory response, relative to animals exclusively exposed to the metal. Animals treated only with P. cupana presented a significant increase in plasma testosterone levels and a significant increase in volumetric proportions of seminiferous tubules, which are indicative of spermatogenic stimulation.
Subject: Animals
Antioxidants
Body Weight
Cadmium
Dietary Supplements
Male
Organ Size
Paullinia
Rats
Rats, Wistar
Seeds
Testis
Testosterone
Rights: fechado
Identifier DOI: 10.1007/s12011-010-8729-7
Address: http://www.ncbi.nlm.nih.gov/pubmed/20495888
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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