Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199282
Type: Artigo de periódico
Title: Exposure To Ethinylestradiol During Prenatal Development And Postnatal Supplementation With Testosterone Causes Morphophysiological Alterations In The Prostate Of Male And Female Adult Gerbils.
Author: Perez, Ana Paula Silva
Biancardi, Manoel Francisco
Góes, Rejane Maira
dos Santos, Fernanda Alcântara
Taboga, Sebastião Roberto
Abstract: Steroids perform significant functions in prostatic development and growth, so that interferences of this equilibrium may predispose the gland to the development of diseases during the life. Embryonic and neonatal exposure to xenoestrogens, many of them with endocrine-disrupting potential, has been related to the induction of disturbances in reproductive system organs. Thus, this study aimed to analyse morphological and immunocytochemical aspects of prostate in both male and female adult gerbils either exposed to ethinylestradiol during the prenatal phase (pregnant females received 10 μg/kg, by gavage) (EE group) or exposed to testosterone (1 mg/kg) during the postnatal period (EE/T group). Serological analysis revealed a rise in estradiol levels in adult males and females of the EE group. A higher incidence of prostatic intraepithelial neoplasia (PIN) was observed in the male and female prostate of the treated groups, besides an increase in collagen and reticular fibres. Immunocytochemistry showed an increase in prostatic epithelial cells immunoreactive to AR and a presence of a smooth muscle layer, evidenced by α actin, in injured regions this way absent in prostatic epithelial buds. These pieces of evidence suggest that the alterations verified in the prostate in adulthood of both sexes may be due to the high oestrogen levels. Either males or females of the EE/T group showed normalized estradiol levels, although prostatic lesions could be observed. While the prostatic gland of male gerbils was more affected than the female prostate, this study showed that the exposure to EE during this critical period of development disrupts the prostate of both sexes in terms of prostatic lesions.
Subject: Animals
Animals, Newborn
Cell Nucleus
Drug Therapy, Combination
Estradiol
Ethinyl Estradiol
Female
Gerbillinae
Male
Organ Size
Pregnancy
Prenatal Exposure Delayed Effects
Prostate
Prostatic Intraepithelial Neoplasia
Prostatic Neoplasms
Sex Factors
Testosterone
Rights: fechado
Identifier DOI: 10.1111/j.1365-2613.2010.00756.x
Address: http://www.ncbi.nlm.nih.gov/pubmed/21314741
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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