Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199276
Type: Artigo de periódico
Title: Geranylgeraniol And 6α,7β-dihydroxyvouacapan-17β-oate Methyl Ester Isolated From Pterodon Pubescens Benth.: Further Investigation On The Antinociceptive Mechanisms Of Action.
Author: Spindola, Humberto M
Servat, Leila
Rodrigues, Rodney A F
Sousa, Ilza M O
Carvalho, João E
Foglio, Mary A
Abstract: The crude alcoholic extracts obtained from Pterodon pubescens Benth. seeds are widely used in Brazilian folk medicine as anti-inflammatory, analgesic, anti-rheumatic tonics and depurative preparations. We previously demonstrated the antinociceptive activity on writhing capsaicin, glutamate, and hot-plate tests of two compounds isolated from P. pubescens: geranylgeraniol (C1) and 6α,7β-dihydroxyvouacapan-17β-oate methyl ester (C2). This work is a continuation of the previous study investigating the possible mechanisms of action for compounds C1 and C2, and the differences between them. The present study demonstrated that when administered intraperitoneally (i.p.): i), compounds C1 and C2 produced significant anti-allodynic activity during the acute phase of the Complete Freund's Adjuvant (CFA)-induced persistent pain model; ii) compound C1 produced significant anti-hypernociception activity in the carrageenan-induced pain model; iii) compound C2 presented a significant loss of activity after p-chlorophenylalanine methyl ester hydrochloride (PCPA) [5-HT synthesis inhibitor] treatment, suggesting that the mechanisms of action could be related to either the synthesis or release of serotonin; iv) compound C1 presented a significant loss of activity after ondansetron (5-HT(3) receptor antagonist) treatment suggesting activity upon 5-HT(3) serotonin receptors; v) compound C1 presented a significant loss of activity after efaroxan (mixed I(1) imidazoline/α(2)-adrenoceptor antagonist) treatment suggesting the participation of this compound upon imidazoline I(1) receptors; and vi) both compounds C1 and C2 did not appear to exert their activity via 5-HT(1A), 5-HT(2A), imidazoline I(2), α(2)-adrenoceptor, nitric oxide, GABA(A), acetylcholine muscarinic, and nicotinic receptors when evaluated in acetic acid-induced nociception.
Subject: Analgesics
Animals
Diterpenes
Fabaceae
Hyperalgesia
Imidazolines
Male
Mice
Serotonin
Rights: fechado
Identifier DOI: 10.1016/j.ejphar.2011.01.025
Address: http://www.ncbi.nlm.nih.gov/pubmed/21296068
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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