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Type: Artigo de periódico
Title: Association Of Matrix Metalloproteinase Gene Polymorphism With Temporomandibular Joint Degeneration.
Author: Planello, Aline C
Campos, Maria I G
Meloto, Carolina B
Secolin, Rodrigo
Rizatti-Barbosa, Célia M
Line, Sergio R P
de Souza, Ana P
Abstract: Temporomandibular joint (TMJ) degeneration is a frequent cause of orofacial pain. Matrix metalloproteinases (MMPs) degrade extracellular matrix components and play an important role in TMJ degeneration. We investigated the frequency of the MMP1 1G/2G polymorphism (rs1799750), the MMP3 5A/6A polymorphism (rs3025058), and the MMP9 C/T polymorphism (rs3918242) in individuals with TMJ degeneration, in order to analyze the association of polymorphisms in these genes with TMJ degeneration. The population studied comprised 117 healthy controls and 115 individuals diagnosed with TMJ degeneration upon examination of magnetic resonance imaging (MRI) and computed tomography (CT) images. Genotypes were determined using PCR restriction fragment length polymorphism (RFLP). Logistic regression analyses revealed an association between the MMP1 2G/2G genotype and degeneration; in contrast, there was no association between either the MMP3 or the MMP9 genotype and degeneration. Our results may indicate a role for the MMP1 polymorphism in TMJ degeneration.
Subject: Adult
Case-control Studies
Chi-square Distribution
Gene Frequency
Linkage Disequilibrium
Logistic Models
Magnetic Resonance Imaging
Mandibular Condyle
Matrix Metalloproteinase 1
Matrix Metalloproteinase 3
Matrix Metalloproteinase 9
Middle Aged
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Temporomandibular Joint Disorders
Tomography, X-ray Computed
Rights: fechado
Identifier DOI: 10.1111/j.1600-0722.2010.00803.x
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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