Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199247
Type: Artigo de periódico
Title: Female Urethral Carcinoma: Evidences To Origin From Skene's Glands.
Author: Reis, Leonardo Oliveira
Billis, Athanase
Ferreira, Fábio T
Ikari, Lia Y
Stellini, Rafael F
Ferreira, Ubirajara
Abstract: Urethral carcinoma is among the rarest neoplasias of the genitourinary tract and its origin is unclear. Prostate-specific antigen (PSA) is considered an evidence of origin from Skene's glands. We considered the origin from these glands in PSA negative cases. We studied 3 patients with urethral carcinoma surgically treated. The surgical specimens were examined including cytochemical and immunohistochemical stains. The possible origin of the tumors was based on a comparative study of normal Skene's glands from autopsies and noninvolved glands in periurethral tumors. The gross findings and the microscopic examination of 2 adenocarcinomas, including the cytochemical and immunohistochemical studies, favor an origin from Skene's glands. The origin from Skene's glands may be established in PSA negative cases. The establishment of this origin in a higher number of urethral carcinomas may have an impact on diagnostic and treatment strategies in the future.
Subject: Adenocarcinoma
Adenocarcinoma, Clear Cell
Aged
Carcinoma, Squamous Cell
Exocrine Glands
Female
Humans
Immunohistochemistry
Keratin-7
Middle Aged
Prostate-specific Antigen
Urethra
Urethral Neoplasms
Rights: fechado
Identifier DOI: 10.1016/j.urolonc.2009.03.019
Address: http://www.ncbi.nlm.nih.gov/pubmed/19450996
Date Issue: -1-Uns- -1
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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