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Type: Artigo de periódico
Title: Quantitative Spot-test Analysis Of Metformin In Pharmaceutical Preparations Using Ultraviolet-visible Diffuse Reflectance Spectroscopy.
Author: Tubino, Matthieu
Bianchessi, Luís Francisco
Vila, Marta M D C
Abstract: A quantitative spot-test for the determination of metformin in pharmaceutical preparations using diffuse UV-visible reflectance is reported. The procedure is quite simple, involving in the formation of a metformin-nickel(II) complex on a glass filter membrane with a later measurement of the reflectance in the spectrophotometer using an integration sphere. The analytical results obtained with commercial products were statistically compared with those resulting from a method recommended by JP and by USP, where complete agreement was observed. The average RSD is 2.5% and the detection (0.009 mol L(-1)) and the quantitation (0.03 mol L(-1)) limits are quite adequate for pharmaceutical analysis.
Subject: Filtration
Hypoglycemic Agents
Indicators And Reagents
Membranes, Artificial
Spectrophotometry, Ultraviolet
Rights: aberto
Identifier DOI: 
Date Issue: 2010
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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