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Type: Artigo de periódico
Title: Herpesvirus Type 7 Infection May Play An Important Role In Individuals With A Genetic Profile Of Susceptibility To Graves' Disease.
Author: Leite, Janaina Luisa
Bufalo, Natassia Elena
Santos, Roberto Bernardo
Romaldini, João Hamilton
Ward, Laura Sterian
Abstract: An inherited profile of genes related to the response to aggressive environmental factors such as viruses and chemicals may be related to an increased susceptibility to Graves' disease (GD). This prospective case-control study was designed to examine the relationship between human herpesviruses (HHV) infection, determined by circulating DNA; tumour protein p53 (TP53) apoptotic ability; and detoxification system genes, and GD. We studied 280 confirmed GD patients paired to 284 controls with respect to environmental exposure. Exclusion criteria included medications that could interfere with thyroid function evaluation and a recent history of viral and bacterial infections. A stepwise regression analysis adjusted for age, gender, and ethnicity established the inheritance of glutathione S-transferase pi 1 (GSTP1) (odds ratio (OR)=3.423; 95% confidence interval (CI)=2.120-5.527; P<0.001) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) variants (OR=1.649; 95% CI=1.012-2.686; P=0.0445) as significant risk factors for the disease. HHV-7 infection was much more common in GD patients (64.64%) than in controls (38.73%; chi(2), P<0.0001), and it increased the risk for GD more than three times (OR=3.133; 95% CI=1.959-5.011; P<0.0001). The inheritance of less efficient Pro/Pro TP53 gene variants significantly increased the risk of GD development (OR=5.196; 95% CI=2.112-12.783; P<0.0001) and also favored HHV-7 infection (OR=2.835; 95% CI=1.100-7.310; P=0.0275). In addition, 72TP53 variants augmented the risk of GD relapse (OR=1.860; 95% CI=1.015-3.410; P=0.0446). We suggest that an inherited genetic profile involving TP53 may favor HHV-7 infection and maintenance, which, in turn, may initiate and perpetuate GD autoimmune process.
Subject: Adult
Case-control Studies
Cytochrome P-450 Cyp1a1
Genetic Predisposition To Disease
Glutathione S-transferase Pi
Glutathione Transferase
Graves Disease
Herpesvirus 7, Human
Middle Aged
Prospective Studies
Regression (psychology)
Risk Factors
Roseolovirus Infections
Tumor Suppressor Protein P53
Young Adult
Citation: European Journal Of Endocrinology / European Federation Of Endocrine Societies. v. 162, n. 2, p. 315-21, 2010-Feb.
Rights: fechado
Identifier DOI: 10.1530/EJE-09-0719
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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