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Type: Artigo de periódico
Title: Mechanisms Of The Gastric Antiulcerogenic Activity Of Anacardium Humile St. Hil On Ethanol-induced Acute Gastric Mucosal Injury In Rats.
Author: Luiz-Ferreira, Anderson
Almeida, Ana Cristina Alves de
Cola, Maíra
Barbastefano, Victor
Almeida, Ana Beatriz Albino de
Batista, Leônia Maria
Farias-Silva, Elisângela
Pellizzon, Cláudia Helena
Hiruma-Lima, Clélia Akiko
Santos, Lourdes Campaner
Vilegas, Wagner
Brito, Alba Regina Monteiro Souza
Abstract: Leaves and bark infusions Anacardium humile St. Hil. (Anacardiaceae), known as in Brazil as cajuzinho do cerrado, have been used in folk medicine as an alternative treatment for ulcers and gastritis. This study evaluated the gastroprotective activity of an ethyl acetate extract of the leaves of A. humile (AcF) and the mechanism involved in this gastroprotection. Pretreatment concentrations (50, 100, 200 mg x kg⁻¹) were administered by gavage. Following a 60 min. period, all the rats were orally administered 1 mL of absolute ethanol. One hour after the administration of ethanol, all groups were sacrificed, and the gastric ulcer index was calculated. Prostaglandin PGE₂ concentration, gastric adherent mucous, and the participation of nitric oxide (NO) and sulfhydryl compounds in the gastroprotection process were also analyzed using the most effective tested dose (50 mg x kg⁻¹). A histological study of the glandular stomach for the evaluation of the epithelial damage and mucus content was also performed. AcF significantly reduced the gastric damage produced by ethanol. This effect was statistically significant for the 50 mg x kg⁻¹ group compared to control. Also, it significantly increased the PGE₂ (by 10-fold) and mucous production, while pretreatment with NG-nitro-L-arginine methyl ester (L-NAME) or N-ethylmaleimide (NEM) completely abolished the gastroprotection. AcF has a protective effect against ethanol, and this effect, might be due to the augmentation of the protective mechanisms of mucosa.
Subject: Anacardium
Anti-ulcer Agents
Gastric Mucosa
Molecular Structure
Plant Extracts
Rats, Wistar
Stomach Ulcer
Rights: aberto
Identifier DOI: 10.3390/molecules15107153
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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